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Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pgen.1002584
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dc.titleGenome-wide association and functional follow-up reveals new loci for kidney function
dc.contributor.authorPattaro C.
dc.contributor.authorKöttgen A.
dc.contributor.authorTeumer A.
dc.contributor.authorGarnaas M.
dc.contributor.authorBöger C.A.
dc.contributor.authorFuchsberger C.
dc.contributor.authorOlden M.
dc.contributor.authorChen M.-H.
dc.contributor.authorTin A.
dc.contributor.authorTaliun D.
dc.contributor.authorLi M.
dc.contributor.authorGao X.
dc.contributor.authorGorski M.
dc.contributor.authorYang Q.
dc.contributor.authorHundertmark C.
dc.contributor.authorFoster M.C.
dc.contributor.authorO'Seaghdha C.M.
dc.contributor.authorGlazer N.
dc.contributor.authorIsaacs A.
dc.contributor.authorLiu C.-T.
dc.contributor.authorSmith A.V.
dc.contributor.authorO'Connell J.R.
dc.contributor.authorStruchalin M.
dc.contributor.authorTanaka T.
dc.contributor.authorLi G.
dc.contributor.authorJohnson A.D.
dc.contributor.authorGierman H.J.
dc.contributor.authorFeitosa M.
dc.contributor.authorHwang S.-J.
dc.contributor.authorAtkinson E.J.
dc.contributor.authorLohman K.
dc.contributor.authorCornelis M.C.
dc.contributor.authorJohansson A.
dc.contributor.authorTönjes A.
dc.contributor.authorDehghan A.
dc.contributor.authorChouraki V.
dc.contributor.authorHolliday E.G.
dc.contributor.authorSorice R.
dc.contributor.authorKutalik Z.
dc.contributor.authorLehtimäki T.
dc.contributor.authorEsko T.
dc.contributor.authorDeshmukh H.
dc.contributor.authorUlivi S.
dc.contributor.authorChu A.Y.
dc.contributor.authorMurgia F.
dc.contributor.authorTrompet S.
dc.contributor.authorImboden M.
dc.contributor.authorKollerits B.
dc.contributor.authorPistis G.
dc.contributor.authorHarris T.B.
dc.contributor.authorLauner L.J.
dc.contributor.authorAspelund T.
dc.contributor.authorEiriksdottir G.
dc.contributor.authorMitchell B.D.
dc.contributor.authorBoerwinkle E.
dc.contributor.authorSchmidt H.
dc.contributor.authorCavalieri M.
dc.contributor.authorRao M.
dc.contributor.authorHu F.B.
dc.contributor.authorDemirkan A.
dc.contributor.authorOostra B.A.
dc.contributor.authorde Andrade M.
dc.contributor.authorTurner S.T.
dc.contributor.authorDing J.
dc.contributor.authorAndrews J.S.
dc.contributor.authorFreedman B.I.
dc.contributor.authorKoenig W.
dc.contributor.authorIllig T.
dc.contributor.authorDöring A.
dc.contributor.authorWichmann H.-E.
dc.contributor.authorKolcic I.
dc.contributor.authorZemunik T.
dc.contributor.authorBoban M.
dc.contributor.authorMinelli C.
dc.contributor.authorWheeler H.E.
dc.contributor.authorIgl W.
dc.contributor.authorZaboli G.
dc.contributor.authorWild S.H.
dc.contributor.authorWright A.F.
dc.contributor.authorCampbell H.
dc.contributor.authorEllinghaus D.
dc.contributor.authorNöthlings U.
dc.contributor.authorJacobs G.
dc.contributor.authorBiffar R.
dc.contributor.authorEndlich K.
dc.contributor.authorErnst F.
dc.contributor.authorHomuth G.
dc.contributor.authorKroemer H.K.
dc.contributor.authorNauck M.
dc.contributor.authorStracke S.
dc.contributor.authorVölker U.
dc.contributor.authorVölzke H.
dc.contributor.authorKovacs P.
dc.contributor.authorStumvoll M.
dc.contributor.authorMägi R.
dc.contributor.authorHofman A.
dc.contributor.authorUitterlinden A.G.
dc.contributor.authorRivadeneira F.
dc.contributor.authorAulchenko Y.S.
dc.contributor.authorPolasek O.
dc.contributor.authorHastie N.
dc.contributor.authorVitart V.
dc.contributor.authorHelmer C.
dc.contributor.authorWang J.J.
dc.contributor.authorRuggiero D.
dc.contributor.authorBergmann S.
dc.contributor.authorKähönen M.
dc.contributor.authorViikari J.
dc.contributor.authorNikopensius T.
dc.contributor.authorProvince M.
dc.contributor.authorKetkar S.
dc.contributor.authorColhoun H.
dc.contributor.authorDoney A.
dc.contributor.authorRobino A.
dc.contributor.authorGiulianini F.
dc.contributor.authorKrämer B.K.
dc.contributor.authorPortas L.
dc.contributor.authorFord I.
dc.contributor.authorBuckley B.M.
dc.contributor.authorAdam M.
dc.contributor.authorThun G.-A.
dc.contributor.authorPaulweber B.
dc.contributor.authorHaun M.
dc.contributor.authorSala C.
dc.contributor.authorMetzger M.
dc.contributor.authorMitchell P.
dc.contributor.authorCiullo M.
dc.contributor.authorKim S.K.
dc.contributor.authorVollenweider P.
dc.contributor.authorRaitakari O.
dc.contributor.authorMetspalu A.
dc.contributor.authorPalmer C.
dc.contributor.authorGasparini P.
dc.contributor.authorPirastu M.
dc.contributor.authorJukema J.W.
dc.contributor.authorProbst-Hensch N.M.
dc.contributor.authorKronenberg F.
dc.contributor.authorToniolo D.
dc.contributor.authorGudnason V.
dc.contributor.authorShuldiner A.R.
dc.contributor.authorCoresh J.
dc.contributor.authorSchmidt R.
dc.contributor.authorFerrucci L.
dc.contributor.authorSiscovick D.S.
dc.contributor.authorvan Duijn C.M.
dc.contributor.authorBorecki I.
dc.contributor.authorKardia S.L.R.
dc.contributor.authorLiu Y.
dc.contributor.authorCurhan G.C.
dc.contributor.authorRudan I.
dc.contributor.authorGyllensten U.
dc.contributor.authorWilson J.F.
dc.contributor.authorFranke A.
dc.contributor.authorPramstaller P.P.
dc.contributor.authorRettig R.
dc.contributor.authorProkopenko I.
dc.contributor.authorWitteman J.C.M.
dc.contributor.authorHayward C.
dc.contributor.authorRidker P.
dc.contributor.authorParsa A.
dc.contributor.authorBochud M.
dc.contributor.authorHeid I.M.
dc.contributor.authorGoessling W.
dc.contributor.authorChasman D.I.
dc.contributor.authorKao W.H.L.
dc.contributor.authorFox C.S.
dc.date.accessioned2019-11-06T09:30:12Z
dc.date.available2019-11-06T09:30:12Z
dc.date.issued2012
dc.identifier.citationPattaro C., Köttgen A., Teumer A., Garnaas M., Böger C.A., Fuchsberger C., Olden M., Chen M.-H., Tin A., Taliun D., Li M., Gao X., Gorski M., Yang Q., Hundertmark C., Foster M.C., O'Seaghdha C.M., Glazer N., Isaacs A., Liu C.-T., Smith A.V., O'Connell J.R., Struchalin M., Tanaka T., Li G., Johnson A.D., Gierman H.J., Feitosa M., Hwang S.-J., Atkinson E.J., Lohman K., Cornelis M.C., Johansson A., Tönjes A., Dehghan A., Chouraki V., Holliday E.G., Sorice R., Kutalik Z., Lehtimäki T., Esko T., Deshmukh H., Ulivi S., Chu A.Y., Murgia F., Trompet S., Imboden M., Kollerits B., Pistis G., Harris T.B., Launer L.J., Aspelund T., Eiriksdottir G., Mitchell B.D., Boerwinkle E., Schmidt H., Cavalieri M., Rao M., Hu F.B., Demirkan A., Oostra B.A., de Andrade M., Turner S.T., Ding J., Andrews J.S., Freedman B.I., Koenig W., Illig T., Döring A., Wichmann H.-E., Kolcic I., Zemunik T., Boban M., Minelli C., Wheeler H.E., Igl W., Zaboli G., Wild S.H., Wright A.F., Campbell H., Ellinghaus D., Nöthlings U., Jacobs G., Biffar R., Endlich K., Ernst F., Homuth G., Kroemer H.K., Nauck M., Stracke S., Völker U., Völzke H., Kovacs P., Stumvoll M., Mägi R., Hofman A., Uitterlinden A.G., Rivadeneira F., Aulchenko Y.S., Polasek O., Hastie N., Vitart V., Helmer C., Wang J.J., Ruggiero D., Bergmann S., Kähönen M., Viikari J., Nikopensius T., Province M., Ketkar S., Colhoun H., Doney A., Robino A., Giulianini F., Krämer B.K., Portas L., Ford I., Buckley B.M., Adam M., Thun G.-A., Paulweber B., Haun M., Sala C., Metzger M., Mitchell P., Ciullo M., Kim S.K., Vollenweider P., Raitakari O., Metspalu A., Palmer C., Gasparini P., Pirastu M., Jukema J.W., Probst-Hensch N.M., Kronenberg F., Toniolo D., Gudnason V., Shuldiner A.R., Coresh J., Schmidt R., Ferrucci L., Siscovick D.S., van Duijn C.M., Borecki I., Kardia S.L.R., Liu Y., Curhan G.C., Rudan I., Gyllensten U., Wilson J.F., Franke A., Pramstaller P.P., Rettig R., Prokopenko I., Witteman J.C.M., Hayward C., Ridker P., Parsa A., Bochud M., Heid I.M., Goessling W., Chasman D.I., Kao W.H.L., Fox C.S. (2012). Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics 8 (3) : e1002584. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1002584
dc.identifier.issn15537390
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161642
dc.description.abstractChronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD. © 2012 Pattaro et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20191101
dc.subjectdextran
dc.subjectCASP9 protein, human
dc.subjectcaspase 9
dc.subjectCDK12 protein, human
dc.subjectcyclin dependent kinase
dc.subjectDDX1 protein, human
dc.subjectDEAD box protein
dc.subjecthelicase
dc.subjectINO80 protein, human
dc.subjectMPPED2 protein, human
dc.subjectphosphodiesterase
dc.subjectAfrican American
dc.subjectarticle
dc.subjectCASP9 gene
dc.subjectCdk1 gene
dc.subjectchronic kidney disease
dc.subjectcontrolled study
dc.subjectDDX1 gene
dc.subjectembryo
dc.subjectethnic group
dc.subjectEuropean
dc.subjectgene
dc.subjectgene function
dc.subjectgene locus
dc.subjectgenetic association
dc.subjectgenome analysis
dc.subjectglomerulus filtration rate
dc.subjecthuman
dc.subjectINO80 gene
dc.subjectkidney clearance
dc.subjectkidney function
dc.subjectMPPED2 gene
dc.subjectnonhuman
dc.subjectpodocyte
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectsingle nucleotide polymorphism
dc.subjectSLC47A1 gene
dc.subjectzebra fish
dc.subjectaged
dc.subjectanimal
dc.subjectCaucasian
dc.subjectchronic kidney failure
dc.subjectfemale
dc.subjectfollow up
dc.subjectgene silencing
dc.subjectgenetics
dc.subjectglomerulus filtration rate
dc.subjectkidney
dc.subjectmale
dc.subjectmeta analysis
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectzebra fish
dc.subjectDanio rerio
dc.subjectAfrican Americans
dc.subjectAged
dc.subjectAnimals
dc.subjectCaspase 9
dc.subjectCyclin-Dependent Kinases
dc.subjectDEAD-box RNA Helicases
dc.subjectDNA Helicases
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectGene Knockdown Techniques
dc.subjectGenome-Wide Association Study
dc.subjectGlomerular Filtration Rate
dc.subjectHumans
dc.subjectKidney
dc.subjectKidney Failure, Chronic
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPhosphoric Diester Hydrolases
dc.subjectZebrafish
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.pgen.1002584
dc.description.sourcetitlePLoS Genetics
dc.description.volume8
dc.description.issue3
dc.description.pagee1002584
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