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|Title:||Global DNA Hypermethylation in Down Syndrome Placenta||Authors:||Jin S.
Chromosomes, Human, Pair 21
Gene Expression Regulation
Promoter Regions, Genetic
Sequence Analysis, DNA
|Issue Date:||2013||Citation:||Jin S., Lee Y.K., Lim Y.C., Zheng Z., Lin X.M., Ng D.P.Y., Holbrook J.D., Law H.Y., Kwek K.Y.C., Yeo G.S.H., Ding C. (2013). Global DNA Hypermethylation in Down Syndrome Placenta. PLoS Genetics 9 (6) : e1003515. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pgen.1003515||Abstract:||Down syndrome (DS), commonly caused by an extra copy of chromosome 21 (chr21), occurs in approximately one out of 700 live births. Precisely how an extra chr21 causes over 80 clinically defined phenotypes is not yet clear. Reduced representation bisulfite sequencing (RRBS) analysis at single base resolution revealed DNA hypermethylation in all autosomes in DS samples. We hypothesize that such global hypermethylation may be mediated by down-regulation of TET family genes involved in DNA demethylation, and down-regulation of REST/NRSF involved in transcriptional and epigenetic regulation. Genes located on chr21 were up-regulated by an average of 53% in DS compared to normal villi, while genes with promoter hypermethylation were modestly down-regulated. DNA methylation perturbation was conserved in DS placenta villi and in adult DS peripheral blood leukocytes, and enriched for genes known to be causally associated with DS phenotypes. Our data suggest that global epigenetic changes may occur early in development and contribute to DS phenotypes. © 2013 Jin et al.||Source Title:||PLoS Genetics||URI:||https://scholarbank.nus.edu.sg/handle/10635/161621||ISSN:||15537390||DOI:||10.1371/journal.pgen.1003515|
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