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Title: No evidence of a common DNA variant profile specific to world class endurance athletes
Authors: Rankinen T.
Fuku N.
Wolfarth B.
Wang G.
Sarzynski M.A.
Alexeev D.G.
Ahmetov I.I.
Boulay M.R.
Cieszczyk P.
Eynon N.
Filipenko M.L.
Garton F.C.
Generozov E.V.
Govorun V.M.
Houweling P.J.
Kawahara T.
Kostryukova E.S.
Kulemin N.A.
Larin A.K.
Maciejewska-Karlowska A.
Miyachi M.
Muniesa C.A.
Murakami H.
Ospanova E.A.
Padmanabhan S.
Pavlenko A.V.
Pyankova O.N.
Santiago C.
Sawczuk M.
Scott R.A.
Uyba V.V.
Yvert T.
Perusse L.
Ghosh S. 
Rauramaa R.
North K.N.
Lucia A.
Pitsiladis Y.
Bouchard C.
Keywords: Article
case control study
controlled study
GALNTL6 gene
genetic association
genetic variability
physical capacity
single nucleotide polymorphism
copy number variation
gene expression
gene frequency
gene locus
genetic heterogeneity
genetic marker
genome-wide association study
human genome
maximal expiratory flow
oxygen consumption
sedentary lifestyle
genetic marker
n acetylgalactosaminyltransferase
polypeptide N-acetylgalactosaminyltransferase
DNA Copy Number Variations
Gene Expression
Gene Frequency
Genetic Heterogeneity
Genetic Loci
Genetic Markers
Genome, Human
Genome-Wide Association Study
Maximal Expiratory Flow Rate
Oxygen Consumption
Physical Endurance
Physical Fitness
Polymorphism, Single Nucleotide
Sedentary Lifestyle
Issue Date: 2016
Citation: Rankinen T., Fuku N., Wolfarth B., Wang G., Sarzynski M.A., Alexeev D.G., Ahmetov I.I., Boulay M.R., Cieszczyk P., Eynon N., Filipenko M.L., Garton F.C., Generozov E.V., Govorun V.M., Houweling P.J., Kawahara T., Kostryukova E.S., Kulemin N.A., Larin A.K., Maciejewska-Karlowska A., Miyachi M., Muniesa C.A., Murakami H., Ospanova E.A., Padmanabhan S., Pavlenko A.V., Pyankova O.N., Santiago C., Sawczuk M., Scott R.A., Uyba V.V., Yvert T., Perusse L., Ghosh S., Rauramaa R., North K.N., Lucia A., Pitsiladis Y., Bouchard C. (2016). No evidence of a common DNA variant profile specific to world class endurance athletes. PLoS ONE 11 (1) : e0147330. ScholarBank@NUS Repository.
Abstract: There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity- matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 at GALNTL6 locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2 = 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases. � 2016 Rankinen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0147330
Appears in Collections:Staff Publications

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