Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0162102
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dc.titleAge-related changes in the cardiometabolic profiles in Singapore resident adult population: Findings from the national health survey 2010
dc.contributor.authorLoh T.P.
dc.contributor.authorMa S.
dc.contributor.authorHeng D.
dc.contributor.authorKhoo C.M.
dc.date.accessioned2019-11-06T07:47:21Z
dc.date.available2019-11-06T07:47:21Z
dc.date.issued2016
dc.identifier.citationLoh T.P., Ma S., Heng D., Khoo C.M. (2016). Age-related changes in the cardiometabolic profiles in Singapore resident adult population: Findings from the national health survey 2010. PLoS ONE 11 (8) : e0162102. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0162102
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161558
dc.description.abstractWe describe the centile trends of the blood pressure, glycemia and lipid profiles as well as renal function of a representative population who participated in the Singapore National Health Survey in 2010. Representative survey population was sampled in two phases, first using geographical/residential dwelling type stratification, followed up ethnicity. 2, 407 survey participants without any self-reported medical or medication history for diabetes mellitus, hypertension and dyslipidemia were included in this analysis. All biochemistry analyses were performed on Roche platforms. After excluding outliers using Tukey's criteria, the results of the remaining participants were subjected to lambda-mu-sigma (LMS) analysis. In men, systolic blood pressure increased linearly with age. By contrast, an upward inflection around late 40s was seen in women. The diastolic blood pressure was highest in men in the late 30s-50s age group, and in women in the late 50s-60s age group. All glycemia-related parameters, i.e. fasting and 2-hour plasma glucose and HbA1c concentrations increased with age, although the rate of increase differed between the tests. Total cholesterol and LDL-cholesterol concentrations increased with age, which became attenuated between the early 30s and late 50s in men, and declined thereafter. In women, total cholesterol and LDLcholesterol concentrations gradually increased with age until late 30s, when there is an upward inflection, plateauing after late 50s. Our findings indicate that diagnostic performance of laboratory tests for diabetes may be age-sensitive. Unfavourable age-related cardiovascular risk profiles suggest that the burden of cardiovascular disease in this population will increase with aging population. © 2016 Loh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourceUnpaywall 20191101
dc.subjectcreatinine
dc.subjecthemoglobin A1c
dc.subjectlow density lipoprotein cholesterol
dc.subjectcholesterol
dc.subjectglucose blood level
dc.subjectlipid
dc.subjectlow density lipoprotein cholesterol
dc.subjectadult
dc.subjectage distribution
dc.subjectaging
dc.subjectArticle
dc.subjectcardiovascular disease
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectdiastolic blood pressure
dc.subjectdyslipidemia
dc.subjectfemale
dc.subjectglomerulus filtration rate
dc.subjecthealth care planning
dc.subjecthealth survey
dc.subjecthemoglobin blood level
dc.subjecthuman
dc.subjecthypertension
dc.subjectkidney function
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnational health service
dc.subjectoral glucose tolerance test
dc.subjectpopulation research
dc.subjectpulse pressure
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectsex difference
dc.subjectSingapore
dc.subjectsystolic blood pressure
dc.subjectage
dc.subjectblood
dc.subjectblood pressure
dc.subjectCardiovascular Diseases
dc.subjectglucose blood level
dc.subjecthealth survey
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectphysiology
dc.subjectstatistics and numerical data
dc.subjectAdult
dc.subjectAge Factors
dc.subjectBlood Glucose
dc.subjectBlood Pressure
dc.subjectCardiovascular Diseases
dc.subjectCholesterol
dc.subjectCholesterol, LDL
dc.subjectFemale
dc.subjectHealth Surveys
dc.subjectHumans
dc.subjectHypertension
dc.subjectLipids
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectSingapore
dc.typeArticle
dc.contributor.departmentBIOMED INST FOR GLOBAL HEALTH RES & TECH
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentDEPT OF MEDICINE
dc.description.doi10.1371/journal.pone.0162102
dc.description.sourcetitlePLoS ONE
dc.description.volume11
dc.description.issue8
dc.description.pagee0162102
dc.published.statePublished
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