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https://doi.org/10.1371/journal.pone.0162102
Title: | Age-related changes in the cardiometabolic profiles in Singapore resident adult population: Findings from the national health survey 2010 | Authors: | Loh T.P. Ma S. Heng D. Khoo C.M. |
Keywords: | creatinine hemoglobin A1c low density lipoprotein cholesterol cholesterol glucose blood level lipid low density lipoprotein cholesterol adult age distribution aging Article cardiovascular disease controlled study diabetes mellitus diastolic blood pressure dyslipidemia female glomerulus filtration rate health care planning health survey hemoglobin blood level human hypertension kidney function major clinical study male national health service oral glucose tolerance test population research pulse pressure risk assessment risk factor sex difference Singapore systolic blood pressure age blood blood pressure Cardiovascular Diseases glucose blood level health survey metabolism middle aged physiology statistics and numerical data Adult Age Factors Blood Glucose Blood Pressure Cardiovascular Diseases Cholesterol Cholesterol, LDL Female Health Surveys Humans Hypertension Lipids Male Middle Aged Singapore |
Issue Date: | 2016 | Citation: | Loh T.P., Ma S., Heng D., Khoo C.M. (2016). Age-related changes in the cardiometabolic profiles in Singapore resident adult population: Findings from the national health survey 2010. PLoS ONE 11 (8) : e0162102. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0162102 | Rights: | Attribution 4.0 International | Abstract: | We describe the centile trends of the blood pressure, glycemia and lipid profiles as well as renal function of a representative population who participated in the Singapore National Health Survey in 2010. Representative survey population was sampled in two phases, first using geographical/residential dwelling type stratification, followed up ethnicity. 2, 407 survey participants without any self-reported medical or medication history for diabetes mellitus, hypertension and dyslipidemia were included in this analysis. All biochemistry analyses were performed on Roche platforms. After excluding outliers using Tukey's criteria, the results of the remaining participants were subjected to lambda-mu-sigma (LMS) analysis. In men, systolic blood pressure increased linearly with age. By contrast, an upward inflection around late 40s was seen in women. The diastolic blood pressure was highest in men in the late 30s-50s age group, and in women in the late 50s-60s age group. All glycemia-related parameters, i.e. fasting and 2-hour plasma glucose and HbA1c concentrations increased with age, although the rate of increase differed between the tests. Total cholesterol and LDL-cholesterol concentrations increased with age, which became attenuated between the early 30s and late 50s in men, and declined thereafter. In women, total cholesterol and LDLcholesterol concentrations gradually increased with age until late 30s, when there is an upward inflection, plateauing after late 50s. Our findings indicate that diagnostic performance of laboratory tests for diabetes may be age-sensitive. Unfavourable age-related cardiovascular risk profiles suggest that the burden of cardiovascular disease in this population will increase with aging population. © 2016 Loh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161558 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0162102 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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