Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0165979
Title: Genetic modulation of c-di-GMP turnover affects multiple virulence traits and bacterial virulence in rice pathogen Dickeya zeae
Authors: Chen Y.
Lv M.
Liao L.
Gu Y.
Liang Z.
Shi Z.
Liu S.
Zhou J.
Zhang L. 
Keywords: bacterial enzyme
cyclic di GMP
cyclic GMP
exoenzyme
plant toxin
unclassified drug
zeamine
bacterial protein
bis(3',5')-cyclic diguanylic acid
cyclic GMP
macrolide
polyamine
virulence factor
zeamine
Article
bacterial flagellum
bacterial gene
bacterial genetics
bacterial metabolism
bacterial virulence
bacterium
biofilm
controlled study
Dickeya zeae
gene mutation
nonhuman
nucleotide metabolism
second messenger
analogs and derivatives
chemistry
Enterobacteriaceae
flagellum
genetic association study
genetics
metabolism
microbiology
mutation
Oryza
pathogenicity
plant disease
protein domain
quantitative trait
virulence
Bacterial Proteins
Biofilms
Cyclic GMP
Enterobacteriaceae
Flagella
Genetic Association Studies
Macrolides
Mutation
Oryza
Plant Diseases
Polyamines
Protein Interaction Domains and Motifs
Quantitative Trait, Heritable
Virulence
Virulence Factors
Issue Date: 2016
Citation: Chen Y., Lv M., Liao L., Gu Y., Liang Z., Shi Z., Liu S., Zhou J., Zhang L. (2016). Genetic modulation of c-di-GMP turnover affects multiple virulence traits and bacterial virulence in rice pathogen Dickeya zeae. PLoS ONE 11 (11) : e0165979. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0165979
Abstract: The frequent outbreaks of rice foot rot disease caused by Dickeya zeae have become a significant concern in rice planting regions and countries, but the regulatory mechanisms that govern the virulence of this important pathogen remain vague. Given that the second messenger cyclic di-GMP (c-di-GMP) is associated with modulation of various virulence-related traits in various microorganisms, here we set to investigate the role of the genes encoding cdi-GMP metabolism in the regulation of the bacterial physiology and virulence by construction all in-frame deletion mutants targeting the annotated c-di-GMP turnover genes in D. zeae strain EC1. Phenotype analyses identified individual mutants showing altered production of exoenzymes and phytotoxins, biofilm formation and bacterial motilities. The results provide useful clues and a valuable toolkit for further characterization and dissection of the regulatory complex that modulates the pathogenesis and persistence of this important bacterial pathogen. © 2016 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161542
ISSN: 19326203
DOI: 10.1371/journal.pone.0165979
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