Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0165979
Title: | Genetic modulation of c-di-GMP turnover affects multiple virulence traits and bacterial virulence in rice pathogen Dickeya zeae | Authors: | Chen Y. Lv M. Liao L. Gu Y. Liang Z. Shi Z. Liu S. Zhou J. Zhang L. |
Keywords: | bacterial enzyme cyclic di GMP cyclic GMP exoenzyme plant toxin unclassified drug zeamine bacterial protein bis(3',5')-cyclic diguanylic acid cyclic GMP macrolide polyamine virulence factor zeamine Article bacterial flagellum bacterial gene bacterial genetics bacterial metabolism bacterial virulence bacterium biofilm controlled study Dickeya zeae gene mutation nonhuman nucleotide metabolism second messenger analogs and derivatives chemistry Enterobacteriaceae flagellum genetic association study genetics metabolism microbiology mutation Oryza pathogenicity plant disease protein domain quantitative trait virulence Bacterial Proteins Biofilms Cyclic GMP Enterobacteriaceae Flagella Genetic Association Studies Macrolides Mutation Oryza Plant Diseases Polyamines Protein Interaction Domains and Motifs Quantitative Trait, Heritable Virulence Virulence Factors |
Issue Date: | 2016 | Citation: | Chen Y., Lv M., Liao L., Gu Y., Liang Z., Shi Z., Liu S., Zhou J., Zhang L. (2016). Genetic modulation of c-di-GMP turnover affects multiple virulence traits and bacterial virulence in rice pathogen Dickeya zeae. PLoS ONE 11 (11) : e0165979. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0165979 | Rights: | Attribution 4.0 International | Abstract: | The frequent outbreaks of rice foot rot disease caused by Dickeya zeae have become a significant concern in rice planting regions and countries, but the regulatory mechanisms that govern the virulence of this important pathogen remain vague. Given that the second messenger cyclic di-GMP (c-di-GMP) is associated with modulation of various virulence-related traits in various microorganisms, here we set to investigate the role of the genes encoding cdi-GMP metabolism in the regulation of the bacterial physiology and virulence by construction all in-frame deletion mutants targeting the annotated c-di-GMP turnover genes in D. zeae strain EC1. Phenotype analyses identified individual mutants showing altered production of exoenzymes and phytotoxins, biofilm formation and bacterial motilities. The results provide useful clues and a valuable toolkit for further characterization and dissection of the regulatory complex that modulates the pathogenesis and persistence of this important bacterial pathogen. © 2016 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161542 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0165979 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1371_journal_pone_0165979.pdf | 5.58 MB | Adobe PDF | OPEN | None | View/Download |
SCOPUSTM
Citations
4
checked on Jan 20, 2021
Page view(s)
103
checked on Jan 15, 2021
Google ScholarTM
Check
Altmetric
This item is licensed under a Creative Commons License