Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0130017
Title: Atrophic patterns of the frontal-subcortical circuits in patients with mild cognitive impairment and Alzheimer's disease
Authors: Zhao H.
Li X.
Wu W. 
Li Z.
Qian L.
Li S.
Zhang B.
Xu Y.
Keywords: aged
Alzheimer disease
Article
brain atrophy
brain size
controlled study
female
frontal gyrus
hippocampus
human
lateral orbitofrontal gyrus
major clinical study
male
middle frontal gyrus
mild cognitive impairment
nuclear magnetic resonance imaging
putamen
risk factor
volumetry
Alzheimer disease
atrophy
automated pattern recognition
brain cortex
case control study
Cognitive Dysfunction
comparative study
follow up
image processing
pathology
procedures
prognosis
Aged
Alzheimer Disease
Atrophy
Case-Control Studies
Cerebral Cortex
Cognitive Dysfunction
Female
Follow-Up Studies
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Pattern Recognition, Automated
Prognosis
Issue Date: 2015
Citation: Zhao H., Li X., Wu W., Li Z., Qian L., Li S., Zhang B., Xu Y. (2015). Atrophic patterns of the frontal-subcortical circuits in patients with mild cognitive impairment and Alzheimer's disease. PLoS ONE 10 (6) : e0130017. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0130017
Rights: Attribution 4.0 International
Abstract: Atrophy of the cortical thickness and gray matter volume are regarded as sensitive markers for the early clinical diagnosis of Alzheimer's disease (AD). This study aimed to investigate differences in atrophy patterns in the frontal-subcortical circuits between MCI and AD, assess whether these differences were essential for the pathologic basis of cognitive impairment. A total of 131 individuals were recruited, including 45 with cognitively normal controls (CN), 46 with MCI, and 40 with AD. FreeSurfer software was used to perform volumetric measurements of the frontal-subcortical circuits from 3.0T magnetic resonance (MR) scans. Data revealed that both MCI and AD subjects had a thinner cortex in the left caudal middle frontal gyrus and the left lateral orbitofrontal gyrus compared with CN individuals. The left lateral orbitofrontal gyrus was also thinner in AD compared with MCI patients. There were no statistically significant differences in the cortical mean curvature among the three groups. Both MCI and AD subjects exhibited smaller bilateral hippocampus volumes compared with CN individuals. The volumes of the bilateral hippocampus and the right putamen were also smaller in AD compared with MCI patients. Logistic regression analyses revealed that the left lateral orbitofrontal gyrus and bilateral hippocampus were risk factors for cognitive impairment. These current results suggest that atrophy was heterogeneous in subregions of the frontal-subcortical circuits in MCI and AD patients. Among these subregions, the reduced thickness of the left lateral orbitofrontal and the smaller volume of the bilateral hippocampus seemed to be markers for predicting cognitive impairment. © 2015 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161507
ISSN: 19326203
DOI: 10.1371/journal.pone.0130017
Rights: Attribution 4.0 International
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This item is licensed under a Creative Commons License Creative Commons