Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0130879
Title: Age-related Vitamin D deficiency is associated with reduced macular ganglion cell complex: A cross-sectional high-definition optical coherence tomography study
Authors: Uro M.
Beauchet O.
Cherif M.
Graffe A.
Milea D. 
Annweiler C.
Keywords: 25 hydroxyvitamin D
calcium
calcifediol
age
aged
Article
body mass
brain size
calcium blood level
cell loss
comorbidity
controlled study
cross-sectional study
dementia
disease association
female
human
macular ganglion cell complex thickness
major clinical study
male
optical coherence tomography
personal autonomy
retina ganglion cell
retinal nerve fiber layer thickness
sex difference
visual acuity
visual field
visual system parameters
vitamin blood level
vitamin D deficiency
blood
complication
Glaucoma, Open-Angle
macular degeneration
nerve fiber
physiology
retina macula lutea
statistical model
vitamin D deficiency
Aged
Calcifediol
Cross-Sectional Studies
Female
Glaucoma, Open-Angle
Humans
Linear Models
Macula Lutea
Macular Degeneration
Male
Nerve Fibers
Retinal Ganglion Cells
Tomography, Optical Coherence
Vitamin D Deficiency
Issue Date: 2015
Citation: Uro M., Beauchet O., Cherif M., Graffe A., Milea D., Annweiler C. (2015). Age-related Vitamin D deficiency is associated with reduced macular ganglion cell complex: A cross-sectional high-definition optical coherence tomography study. PLoS ONE 10 (6) : e0130879. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0130879
Abstract: Background Vitamin D deficiency is associated with smaller volume of optic chiasm in older adults, indicating a possible loss of the visual axons and their cellular bodies. Our objective was to determine whether vitamin D deficiency in older adults is associated with reduced thickness of the ganglion cell complex(GCC) and of the retinal nerve fibre layer(RNFL), as measured with high-definition optical coherence tomography(HD-OCT). Methods Eighty-five French older community-dwellers without open-angle glaucoma and patent agerelated macular degeneration(mean, 71.1±4.7years; 45.9%female) from the GAIT study were separated into 2 groups according to serum 25OHD level(i.e., deficient 25nmol/L or sufficient>25nmol/L). Measurements of GCC and RNFL thickness were performed using HD-OCT. Age, gender, body mass index, number of comorbidities, dementia, functional autonomy, intracranial volume, visual acuity, serum calcium concentration and season of testing were considered as potential confounders. Results Mean serum 25OHD concentration was 58.4±26.8nmol/L. Mean logMAR visual acuity was 0.03±0.06. Mean visual field mean deviation was -1.25±2.29dB. Patients with vitamin D deficiency(n=11) had a reduced mean GCC thickness compared to those without vitamin D deficiency(72.1±7.4?m versus 77.5±7.5?m, P=0.028). There was no difference of the mean RNFL thickness in these two groups(P=0.133). After adjustment for potential confounders, vitamin D deficiency was associated with reduced GCC thickness(ß=-5.12, P=0.048) but not RNFL thickness(ß=-9.98, P=0.061). Specifically, vitamin D deficiency correlated with the superior medial GCC area(P=0.017) and superior temporal GCC area(P=0.010). Conclusions Vitamin D deficiency in older patients is associated with reduced mean GCC thickness, which can represent an early stage of optic nerve damage, prior to RNFL loss. Copyright: © 2015 Uro et al.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161505
ISSN: 19326203
DOI: 10.1371/journal.pone.0130879
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