Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0130253
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dc.titleSynthesis mechanism and thermal optimization of an economical mesoporous material using silica: Implications for the effective removal or delivery of ibuprofen
dc.contributor.authorKittappa S.
dc.contributor.authorCui M.
dc.contributor.authorRamalingam M.
dc.contributor.authorIbrahim S.
dc.contributor.authorKhim J.
dc.contributor.authorYoon Y.
dc.contributor.authorSnyder S.A.
dc.contributor.authorJang M.
dc.date.accessioned2019-11-06T01:28:49Z
dc.date.available2019-11-06T01:28:49Z
dc.date.issued2015
dc.identifier.citationKittappa S., Cui M., Ramalingam M., Ibrahim S., Khim J., Yoon Y., Snyder S.A., Jang M. (2015). Synthesis mechanism and thermal optimization of an economical mesoporous material using silica: Implications for the effective removal or delivery of ibuprofen. PLoS ONE 10 (7) : e0130253. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0130253
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161499
dc.description.abstractMesoporous silica materials (MSMs) were synthesized economically using silica (SiO<inf>2</inf>) as a precursor via a modified alkaline fusion method. The MSM prepared at 500°C (MSM-500) had the highest surface area, pore size, and volume, and the results of isotherms and the kinetics of ibuprofen (IBP) removal indicated that MSM-500 had the highest sorption capacity and fastest removal speed vs. SBA-15 and zeolite. Compared with commercial granular activated carbon (GAC), MSM-500 had a 100 times higher sorption rate at neutral pH. IBP uptake by MSM-500 was thermodynamically favorable at room temperature, which was interpreted as indicating relatively weak bonding because the entropy (?<inf>adsS</inf>, -0.07 J mol-1 K-1) was much smaller. Five times recycling tests revealed that MSM-500 had 83-87% recovery efficiencies and slower uptake speeds due to slight deformation of the outer pore structure. In the IBP delivery test, MSM-500 drug loading was 41%, higher than the reported value of SBA-15 (31%). The in vitro release of IBP was faster, almost 100%, reaching equilibrium within a few hours, indicating its effective loading and unloading characteristics. A cost analysis study revealed that the MSM was 10-70 times cheaper than any other mesoporous silica material for the removal or delivery of IBP. © 2015 Kittappa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20191101
dc.subjectibuprofen
dc.subjectsilicon dioxide
dc.subjectdrug carrier
dc.subjectibuprofen
dc.subjectnonsteroid antiinflammatory agent
dc.subjectSBA-15
dc.subjectsilicon dioxide
dc.subjectadsorption
dc.subjectArticle
dc.subjectcost benefit analysis
dc.subjectdrug delivery system
dc.subjectdrug release
dc.subjecthigh temperature
dc.subjectinfrared spectroscopy
dc.subjectisotherm
dc.subjectmaterial state
dc.subjectparticle size
dc.subjectpH
dc.subjectsurface property
dc.subjectsynthesis
dc.subjectthermodynamics
dc.subjectthermostability
dc.subjecttransmission electron microscopy
dc.subjectX ray diffraction
dc.subjectchemistry
dc.subjecteconomics
dc.subjectisolation and purification
dc.subjectporosity
dc.subjectAdsorption
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectDrug Carriers
dc.subjectIbuprofen
dc.subjectPorosity
dc.subjectSilicon Dioxide
dc.subjectThermodynamics
dc.typeArticle
dc.contributor.departmentNUS ENVIRONMENTAL RESEARCH INSTITUTE
dc.description.doi10.1371/journal.pone.0130253
dc.description.sourcetitlePLoS ONE
dc.description.volume10
dc.description.issue7
dc.description.pagee0130253
dc.published.statePublished
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This item is licensed under a Creative Commons License Creative Commons