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Title: | Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes | Authors: | Walter V. Yin X. Wilkerson M.D. Cabanski C.R. Zhao N. Du Y. Ang M.K. Hayward M.C. Salazar A.H. Hoadley K.A. Fritchie K. Sailey C.G. Weissler M.C. Shockley W.W. Zanation A.M. Hackman T. Thorne L.B. Funkhouser W.D. Muldrew K.L. Olshan A.F. Randell S.H. Wright F.A. Shores C.G. Hayes D.N. |
Keywords: | kelch like ECH associated protein 1 oncoprotein protein NFE2L2 protein TP63 transcription factor Sox2 unclassified drug adult article cancer survival chromosome 3q chromosome loss clinical feature DNA sequence EGFR gene female gene dosage genetic association genetic gain genetic marker genetic variability genome analysis head and neck cancer human lung squamous cell carcinoma major clinical study male molecular pathology nucleotide sequence oncogene oxidative stress papillomavirus infection PIK3CA gene recurrence free survival |
Issue Date: | 2013 | Citation: | Walter V., Yin X., Wilkerson M.D., Cabanski C.R., Zhao N., Du Y., Ang M.K., Hayward M.C., Salazar A.H., Hoadley K.A., Fritchie K., Sailey C.G., Weissler M.C., Shockley W.W., Zanation A.M., Hackman T., Thorne L.B., Funkhouser W.D., Muldrew K.L., Olshan A.F., Randell S.H., Wright F.A., Shores C.G., Hayes D.N. (2013). Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes. PLoS ONE 8 (2) : e56823. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0056823 | Rights: | Attribution 4.0 International | Abstract: | Head and neck squamous cell carcinoma (HNSCC) is a frequently fatal heterogeneous disease. Beyond the role of human papilloma virus (HPV), no validated molecular characterization of the disease has been established. Using an integrated genomic analysis and validation methodology we confirm four molecular classes of HNSCC (basal, mesenchymal, atypical, and classical) consistent with signatures established for squamous carcinoma of the lung, including deregulation of the KEAP1/NFE2L2 oxidative stress pathway, differential utilization of the lineage markers SOX2 and TP63, and preference for the oncogenes PIK3CA and EGFR. For potential clinical use the signatures are complimentary to classification by HPV infection status as well as the putative high risk marker CCND1 copy number gain. A molecular etiology for the subtypes is suggested by statistically significant chromosomal gains and losses and differential cell of origin expression patterns. Model systems representative of each of the four subtypes are also presented. © 2013 Walter et al. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161341 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0056823 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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