Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0056823
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dc.titleMolecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes
dc.contributor.authorWalter V.
dc.contributor.authorYin X.
dc.contributor.authorWilkerson M.D.
dc.contributor.authorCabanski C.R.
dc.contributor.authorZhao N.
dc.contributor.authorDu Y.
dc.contributor.authorAng M.K.
dc.contributor.authorHayward M.C.
dc.contributor.authorSalazar A.H.
dc.contributor.authorHoadley K.A.
dc.contributor.authorFritchie K.
dc.contributor.authorSailey C.G.
dc.contributor.authorWeissler M.C.
dc.contributor.authorShockley W.W.
dc.contributor.authorZanation A.M.
dc.contributor.authorHackman T.
dc.contributor.authorThorne L.B.
dc.contributor.authorFunkhouser W.D.
dc.contributor.authorMuldrew K.L.
dc.contributor.authorOlshan A.F.
dc.contributor.authorRandell S.H.
dc.contributor.authorWright F.A.
dc.contributor.authorShores C.G.
dc.contributor.authorHayes D.N.
dc.date.accessioned2019-11-04T06:29:27Z
dc.date.available2019-11-04T06:29:27Z
dc.date.issued2013
dc.identifier.citationWalter V., Yin X., Wilkerson M.D., Cabanski C.R., Zhao N., Du Y., Ang M.K., Hayward M.C., Salazar A.H., Hoadley K.A., Fritchie K., Sailey C.G., Weissler M.C., Shockley W.W., Zanation A.M., Hackman T., Thorne L.B., Funkhouser W.D., Muldrew K.L., Olshan A.F., Randell S.H., Wright F.A., Shores C.G., Hayes D.N. (2013). Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes. PLoS ONE 8 (2) : e56823. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0056823
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161341
dc.description.abstractHead and neck squamous cell carcinoma (HNSCC) is a frequently fatal heterogeneous disease. Beyond the role of human papilloma virus (HPV), no validated molecular characterization of the disease has been established. Using an integrated genomic analysis and validation methodology we confirm four molecular classes of HNSCC (basal, mesenchymal, atypical, and classical) consistent with signatures established for squamous carcinoma of the lung, including deregulation of the KEAP1/NFE2L2 oxidative stress pathway, differential utilization of the lineage markers SOX2 and TP63, and preference for the oncogenes PIK3CA and EGFR. For potential clinical use the signatures are complimentary to classification by HPV infection status as well as the putative high risk marker CCND1 copy number gain. A molecular etiology for the subtypes is suggested by statistically significant chromosomal gains and losses and differential cell of origin expression patterns. Model systems representative of each of the four subtypes are also presented. © 2013 Walter et al.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20191101
dc.subjectkelch like ECH associated protein 1
dc.subjectoncoprotein
dc.subjectprotein NFE2L2
dc.subjectprotein TP63
dc.subjecttranscription factor Sox2
dc.subjectunclassified drug
dc.subjectadult
dc.subjectarticle
dc.subjectcancer survival
dc.subjectchromosome 3q
dc.subjectchromosome loss
dc.subjectclinical feature
dc.subjectDNA sequence
dc.subjectEGFR gene
dc.subjectfemale
dc.subjectgene dosage
dc.subjectgenetic association
dc.subjectgenetic gain
dc.subjectgenetic marker
dc.subjectgenetic variability
dc.subjectgenome analysis
dc.subjecthead and neck cancer
dc.subjecthuman
dc.subjectlung squamous cell carcinoma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmolecular pathology
dc.subjectnucleotide sequence
dc.subjectoncogene
dc.subjectoxidative stress
dc.subjectpapillomavirus infection
dc.subjectPIK3CA gene
dc.subjectrecurrence free survival
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1371/journal.pone.0056823
dc.description.sourcetitlePLoS ONE
dc.description.volume8
dc.description.issue2
dc.description.pagee56823
dc.published.statePublished
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