SURFACE ADSORPTION STUDIES OF PRIMARY STRUCTURED DNA AND DNA NANOSTRUCTURES ONTO 2D MOS2 NANOSHEETS

Abstract

Due to high biocompatibility and tailorable properties, DNA-based nanostructures are widely studied in biosensor and nanomedicine applications. The restriction for using DNA-based nanostructures lie in the purification processes which have low product yield and tedious steps involved. MoS2 nanosheets are chosen to test for its purification efficiency as MoS2 is shown to have discriminating properties between single stranded DNA and double stranded DNA. Adsorption studies of different DNA nanostructures are tested to see the adsorption capacity of MoS2. From the adsorption studies, it has been observed that MoS2 has high affinity to plasmid DNA, so the use of MoS2 as a gene carrier is tested for its delivery performance.