Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/161257
Title: ROLE OF THE INNATE IMMUNITY IN CHRONIC HEPATITIS B REACTIVATION AND LIVER INJURY
Authors: WANG TONG
ORCID iD:   orcid.org/0000-0001-7151-7304
Keywords: Chronic hepatitis B, Quasispecies, Reactivation, Liver injury, Virus-host interactions, Phylogenetic analysis
Issue Date: 28-Feb-2019
Citation: WANG TONG (2019-02-28). ROLE OF THE INNATE IMMUNITY IN CHRONIC HEPATITIS B REACTIVATION AND LIVER INJURY. ScholarBank@NUS Repository.
Abstract: Mechanisms of liver injury in chronic hepatitis B patients remains unclear. High replication and mutation rates of the hepatitis B virus (HBV), under a competitive environment, often generates a dynamic quasispecies pool consisted of variants with clinical implications. In a cohort of 32 patients, sequencing of the HBV genomes has revealed unique HBV evolutionary patterns. Variants associated with decreased or abolished production of the hepatitis B e antigen (HBeAg) were frequently detected in patients. However, mutations within the basal core promoter region was more frequently detected in reactivation patients with liver injury. Competitive inhibition of variants carrying mutations within the conserved binding region for the HBV entry receptor were also observed, in concurrent with the rebound of viremia and liver injury. Analysis of amino acid residues under positive selection has further identified potential immune escape mutations in the HBV core antigen and X protein.
URI: https://scholarbank.nus.edu.sg/handle/10635/161257
Appears in Collections:Master's Theses (Open)

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