Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0202147
Title: Surveillance for respiratory syncytial virus and parainfluenza virus among patients hospitalized with pneumonia in Sarawak, Malaysia
Authors: Fieldhouse J.K.
Toh T.-H.
Lim W.-H.
Ting J.
Ha S.-J.
Hii K.-C.
Kong C.-I.
Wong T.-M.
Wong S.-C.
Warkentien T.E.
Gray G.C. 
Keywords: adolescent
adult
Article
child
cross-sectional study
human
Human parainfluenza virus 1
Human parainfluenza virus 2
Human parainfluenza virus 3
Human parainfluenza virus 4
Human respiratory syncytial virus
Human respiratory syncytial virus A
Human respiratory syncytial virus B
infant
infection risk
major clinical study
Malaysia
molecular diagnosis
nonhuman
Paramyxovirinae
pilot study
pneumonia
prevalence
real time polymerase chain reaction
reverse transcription polymerase chain reaction
risk factor
throat culture
virus identification
classification
female
genetics
health survey
hospitalization
Human respiratory syncytial virus
Malaysia
male
newborn
odds ratio
paramyxovirus infection
preschool child
respiratory syncytial virus infection
virology
virus pneumonia
young adult
Adolescent
Child
Child, Preschool
Cross-Sectional Studies
Female
Hospitalization
Humans
Infant
Infant, Newborn
Malaysia
Male
Odds Ratio
Paramyxoviridae Infections
Pneumonia, Viral
Prevalence
Public Health Surveillance
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus, Human
Risk Factors
Young Adult
Issue Date: 2018
Citation: Fieldhouse J.K., Toh T.-H., Lim W.-H., Ting J., Ha S.-J., Hii K.-C., Kong C.-I., Wong T.-M., Wong S.-C., Warkentien T.E., Gray G.C. (2018). Surveillance for respiratory syncytial virus and parainfluenza virus among patients hospitalized with pneumonia in Sarawak, Malaysia. PLoS ONE 13 (8) : e0202147. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0202147
Abstract: Background: Respiratory syncytial virus (RSV) and parainfluenza virus (PIV) are frequent causes of pneumonia and death among children at Sibu and Kapit Hospitals in Sarawak, Malaysia. Objectives To determine the prevalence and risk factors for RSV subtypes A and B and PIV types 1±4 among patients hospitalized with pneumonia. Methods: In a cross-sectional, pilot study nasopharyngeal swabs were studied with real-time reverse transcription polymerase chain reaction assays. Concurrently, we helped Sibu and Kapit Hospitals adapt their first molecular diagnostics for RSV and PIV. Results: Of 129 specimens collected (June to July 2017), 39 tested positive for RSV-A (30.2%), two were positive for RSV B (1.6%), one was positive for PIV-3 (0.8%) and one was positive for PIV-4 (0.8%). No samples were positive for PIV-1 or PIV-2. Of the 39 RSV-A positive specimens, 46.2% were collected from children under one year of age and only 5.1% were from patients over the age of 18. A multivariable analysis found the odds of children <1 year of age testing positive for RSV-A were 32.7 (95% CI: 3.9, 276.2) times larger than >18 years of age, and the odds of patients hospitalized at Kapit Hospital testing positive for RSV-A were 3.2 (95% CI: 1.3, 7.8) times larger than patients hospitalized at Sibu Hospital. Conclusion: This study found an unusually high prevalence of RSV-A among pneumonia patients admitted to the two hospitals. Subsequently, Sibu Hospital adapted the molecular assays with the goal of providing more directed care for such pneumonia patients. © 2018 Public Library of Science. All rights reserved.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161240
ISSN: 19326203
DOI: 10.1371/journal.pone.0202147
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