Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0173291
Title: Decline in changing montreal cognitive assessment (MoCA) scores is associated withpost-stroke cognitive decline determined by a formal neuropsychological evaluation
Authors: Tan H.H.
Xu J.
Teoh H.L. 
Chan B.P.-L.
Seet R.C.S. 
Venketasubramanian N. 
Sharma V.K. 
Chen C.L.-H. 
Dong Y.
Keywords: adult
Article
cerebrovascular accident
cognitive defect
dementia
disease course
disease severity
female
follow up
human
major clinical study
male
mental deterioration
middle aged
Mini Mental State Examination
Montreal cognitive assessment
neuropsychological test
psychoeducation
scoring system
transient ischemic attack
aged
Cognitive Dysfunction
complication
dementia
educational status
neuropsychological test
risk factor
Adult
Aged
Cognitive Dysfunction
Dementia
Educational Status
Female
Follow-Up Studies
Humans
Ischemic Attack, Transient
Male
Middle Aged
Neuropsychological Tests
Risk Factors
Stroke
Issue Date: 2017
Citation: Tan H.H., Xu J., Teoh H.L., Chan B.P.-L., Seet R.C.S., Venketasubramanian N., Sharma V.K., Chen C.L.-H., Dong Y. (2017). Decline in changing montreal cognitive assessment (MoCA) scores is associated withpost-stroke cognitive decline determined by a formal neuropsychological evaluation. PLoS ONE 12 (3) : e0173291. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0173291
Abstract: Objectives We aimed to examine changes in the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) scores within a one-year period after stroke/transient ischemic attack (TIA) in associating cognitive decline determined by a formal neuropsychological test battery. Methods Patients with ischemic stroke/TIA received MoCA and MMSE at baseline within 14 days after stroke/TIA, at 3 lusmn;6 months and 1-year follow-ups. The scores of MoCA and MMSE were considered to have declined if there were a reduction of -2 points in the respective scores measured across two time points. The decline in neuropsychological diagnosis transitional status was defined by a category transition from no cognitive impairment or any cognitive impairment to a more severe cognitive impairment or dementia. Results 275 patients with a mean age of 59.8 lusmn; 11.6 years, and education of 7.7 lusmn; 4.3 years completed all the assessments at baseline, 3 lusmn;6 months and 1-year follow-ups. A decline in MoCA scores from 3 lusmn;6 months to 1 year was associated with higher risk of decline in diagnosis transitional status (odd ratio = 3.21, p = 0.004) in the same time period whereas there was no association with a decline in MMSE scores. Conclusions The decline in MoCA scores from 3 lusmn;6 months to 1 year after stroke/TIA has three times higher risk for decline in the diagnosis transitional status. The decline of MoCA scores (reduction > 2points) is associated with the decline in neuropsychological diagnosis transitional status. © 2017 Tan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161202
ISSN: 19326203
DOI: 10.1371/journal.pone.0173291
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