Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/161046
DC Field | Value | |
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dc.title | Pre-clinical studies on pharmacokinetics and pharmacodynamics of col-3, a matrix metalloproteinase inhibitor: Single agent and in combination with doxorubicin | |
dc.contributor.author | LI JING | |
dc.date.accessioned | 2019-10-31T18:04:30Z | |
dc.date.available | 2019-10-31T18:04:30Z | |
dc.date.issued | 2006-01-06 | |
dc.identifier.citation | LI JING (2006-01-06). Pre-clinical studies on pharmacokinetics and pharmacodynamics of col-3, a matrix metalloproteinase inhibitor: Single agent and in combination with doxorubicin. ScholarBank@NUS Repository. | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/161046 | |
dc.description.abstract | <P>THIS WAS AN EXPLORATORY PRECLINICAL STUDY ON THE POTENTIAL COMBINATION CHEMOTHERAPY OF COL-3, A MATRIX METALLOPROTEINASE INHIBITOR, WITH DOXORUBICIN (DOX), A CYTOTOXIC AGENT. COL-3 PHARMACOKINETICS AND COL-3/DOX PHARMACOKINETIC INTERACTION WERE EXAMINED IN RATS. ALSO, IN VIVO AND IN VITRO ANTITUMOR ACTIVITIES OF COL-3, GIVEN ALONE OR WITH DOX, WERE ASSESSED. COL-3 PHARMACOKINETICS WAS CHARACTERIZED BY A DISSOLUTION-RATE LIMITED ABSORPTION AND A SIGNIFICANT INTESTINAL EXCRETION, WHICH MAY ACCOUNT, IN PART, FOR THE LARGE PHARMACOKINETIC VARIABILITY OBSERVED IN PATIENTS. DOX-INDUCED GI TOXICITY CAUSED SIGNIFICANT REDUCTION IN COL-3 ORAL ABSORPTION, WARNING PHARMACOKINETIC INTERACTIONS BETWEEN COL-3 AND OTHER CYTOTOXIC AGENTS MAY BE POSSIBLE. COL-3 DID NOT SHOW APPARENT ANTITUMOR ACTIVITY, NOR POTENTIATE DOX ANTITUMOR EFFECT, IN MCF-7 BREAST CANCER ORTHOTOPIC MODEL. COL-3/DOX COMBINATION PRODUCED AN ANTAGONISTIC AND ADDITIVE EFFECT ON MCF-7 AND MDA-MB-231 CELLS, RESPECTIVELY. TO | |
dc.language.iso | en | |
dc.subject | COL-3; matrix metalloproteinase inhibitor; doxorubicin; pharmacokinetics; pharmacodynamics; drug interaction | |
dc.type | Thesis | |
dc.contributor.department | PHARMACY | |
dc.contributor.supervisor | CHAN WING YUEN, ELI | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
Appears in Collections: | Ph.D Theses (Open) |
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LiJ.pdf | 2.01 MB | Adobe PDF | OPEN | None | View/Download |
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