Please use this identifier to cite or link to this item: https://doi.org/10.1002/acn3.50834
Title: Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed
Authors: Lioutas, Vasileios-Arsenios
Goyal, Nitin
Katsanos, Aristeidis H
Krogias, Christos
Zand, Ramin
Vijay Kumar Sharma 
Varelas, Panayiotis
Malhotra, Konark
Paciaroni, Maurizio
Sharaf, Aboubakar
Chang, Jason
Kargiotis, Odysseas
Pandhi, Abhi
Schroeder, Christoph
Tsantes, Argyrios
Boviatsis, Efstathios
Mehta, Chandan
Mitsias, Panayiotis D
Selim, Magdy H
Alexandrov, Andrei V
Tsivgoulis, Georgios
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
SMALL VESSEL DISEASE
CEREBRAL MICROBLEEDS
ORAL ANTICOAGULANTS
ATRIAL-FIBRILLATION
HEMORRHAGE RISK
ISCHEMIC-STROKE
METAANALYSIS
Issue Date: 10-Jul-2019
Publisher: WILEY
Citation: Lioutas, Vasileios-Arsenios, Goyal, Nitin, Katsanos, Aristeidis H, Krogias, Christos, Zand, Ramin, Vijay Kumar Sharma, Varelas, Panayiotis, Malhotra, Konark, Paciaroni, Maurizio, Sharaf, Aboubakar, Chang, Jason, Kargiotis, Odysseas, Pandhi, Abhi, Schroeder, Christoph, Tsantes, Argyrios, Boviatsis, Efstathios, Mehta, Chandan, Mitsias, Panayiotis D, Selim, Magdy H, Alexandrov, Andrei V, Tsivgoulis, Georgios (2019-07-10). Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY 6 (8). ScholarBank@NUS Repository. https://doi.org/10.1002/acn3.50834
Abstract: © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1–3) vs. 7(4–11); P < 0.001]; ≥5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01–0.83; P = 0.034).
Source Title: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/158045
ISSN: 2328-9503
DOI: 10.1002/acn3.50834
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