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Title: The ancient origin of NF-kB/IkB and thioredoxin and their roles in immune response
Keywords: Horseshoe crab, IkB, immune response, NF-kB, thioredoxin, signal transduction
Issue Date: 26-Jan-2007
Citation: WANG XIAOWEI (2007-01-26). The ancient origin of NF-kB/IkB and thioredoxin and their roles in immune response. ScholarBank@NUS Repository.
Abstract: This thesis reports the discovery and characterization of a primitive but functional NF-kB/IkB cascade in a a??living fossila??, the horseshoe crab, demonstrating the earliest origin of this signaling cascade. The horseshoe crab NF-kB/IkB homologues share numerous signature motifs with their vertebrate orthologues. In vitro and in vivo functional studies showed that the ancient NF-kB pathway plays a fundamental role in regulating the expression of immune defense molecules and is functionally comparable to that of the Drosophila and mammals, suggesting that the roles of NF-kB and IkB have co-evolved through evolution. Furthermore, we discovered a novel 16 kDa thioredoxin from the horseshoe crab, designated Cr-TRX1. Although the Cr-TRX1 is larger than the classical 12 kDa counterpart and contains an atypical catalytic motif, it possesses the classical thioredoxin activity. Cr-TRX1 could activate the NF-kB activity by enhancing its DNA-binding activity, suggesting possible roles of the Cr-TRX1 in modulating NF-kB signaling pathway.
Appears in Collections:Ph.D Theses (Open)

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