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Title: Studies on the intracellular signalling pathways triggered by the anaphylatoxin C5a in human phagocytic cells
Keywords: Signaling, C5a, Phagocytic cells, Sphingosine kinase, Phospholipase D, Antisense knockdown
Issue Date: 1-Mar-2007
Citation: FARAZEELA BINTE MOHD IBRAHIM (2007-03-01). Studies on the intracellular signalling pathways triggered by the anaphylatoxin C5a in human phagocytic cells. ScholarBank@NUS Repository.
Abstract: Anaphylatoxins play a key role in inflammatory responses and host defense. However, they are often associated with several pathologies. The anaphylatoxin C5a is generated from the cleavage of the fifth component of the complement system. C5a may either act alone or in concert with other factors to stimulate mediators of both chronic and acute inflammation. Even though the significance of C5a in inflammatory diseases is well recognized, the mechanisms regulating C5a-triggered intracellular signaling pathways are still poorly understood. It is with this in mind that we decided to investigate the nature of phospholipid signaling pathways triggered by C5a in phagocytic cells. The phospholipid modifying enzymes sphingosine kinase and phospholipase D are emerging as important signaling molecules. By using pharmacological inhibitors and antisense oligonucleotides, we managed to show that SPHK1 and PLD are key players in the proinflammatory responses triggered by macrophages and neutrophils stimulated by the anaphylatoxin C5a.
Appears in Collections:Ph.D Theses (Open)

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