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Title: Anti-tumor mechanisms of Luteolin, a major Flavonoid oF Chrysanthemum Morifolium
Keywords: chrysanthemum, luteolin, apoptosis, TNF, TRAIL, cisplatin
Issue Date: 8-Nov-2006
Citation: SHI RANXIN (2006-11-08). Anti-tumor mechanisms of Luteolin, a major Flavonoid oF Chrysanthemum Morifolium. ScholarBank@NUS Repository.
Abstract: Luteolin was identified as one of the most abundant components in the chrysanthemum fraction showing the most potent cytotoxicity against human cancer cells. In addition to its anti-tumor effect when used alone, luteolin significantly sensitized TNFI?-induced apoptosis through inhibition of nuclear transcription factor-kappaB and augmentation of c-Jun N-terminal kinase activation. Luteolin also significantly sensitized the apoptosis induced by TRAIL through down-regulation of X-linked inhibitor of apoptosis protein, which was due to enhanced ubiquitination and proteasomal degradation. Furthermore, luteolin was able to enhance the anti-cancer effect of cisplatin through stablization of p53 protein. Finally, the anti-cancer potential of a combination of luteolin and cisplatin was confirmed in a xenograft nude mice model. The evidence from both in vitro and in vivo experiments clearly demonstrates the anti-tumor potential of luteolin as a chemo-sensitizer in cancer therapy.
Appears in Collections:Ph.D Theses (Open)

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