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https://doi.org/10.1093/ije/dyy291
Title: | Prospective associations of maternal choline status with offspring body composition in the first 5 years of life in two large mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort | Authors: | van Lee L Crozier SR Aris IM Tint MT Sadananthan SA Michael N Quah PL Robinson SM Inskip HM Harvey NC Barker M Cooper C Velan SS Lee YS Fortier MV Yap F Gluckman PD Tan KH Shek LP Chong YS Godfrey KM Chong MFF |
Keywords: | choline pregnancy offspring body composition birth size |
Issue Date: | 11-Jan-2019 | Citation: | van Lee L, Crozier SR, Aris IM, Tint MT, Sadananthan SA, Michael N, Quah PL, Robinson SM, Inskip HM, Harvey NC, Barker M, Cooper C, Velan SS, Lee YS, Fortier MV, Yap F, Gluckman PD, Tan KH, Shek LP, Chong YS, Godfrey KM, Chong MFF (2019-01-11). Prospective associations of maternal choline status with offspring body composition in the first 5 years of life in two large mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort. International Journal of Epidemiology 48 (2) : 433-444. ScholarBank@NUS Repository. https://doi.org/10.1093/ije/dyy291 | Abstract: | Background: Choline status has been positively associated with weight and fat
mass in animal and human studies. As evidence examining maternal circulating
choline concentrations and offspring body composition in human infants/children
is lacking we investigated this in two cohorts. Methods: Maternal choline concentrations were measured in the UK Southampton Women's Survey (SWS; serum n?=?985 11?weeks' gestation) and Singapore Growing Up Towards healthy Outcomes (GUSTO); n?=?955 26-28?weeks' gestation) mother-offspring cohorts. Offspring anthropometry was measured at birth and up to age 5?years. Body fat mass was determined using dual-energy x-ray absorptiometry at birth and age 4?years for SWS; and using air-displacement plethysmography at birth and age 5?years for GUSTO. Linear-regression analyses were performed, adjusting for confounders. Results: In SWS higher maternal choline concentrations were associated with higher neonatal total body fat mass {??=?0.60 standard deviation [SD]/5?µmol/L maternal choline [95% confidence interval (CI) 0.04-1.16]} and higher subscapular skinfold thickness [??=?0.55?mm/5?µmol/L (95% CI 0.12-1.00)] at birth. In GUSTO, higher maternal choline concentrations were associated with higher neonatal body mass index-for-age z-score [??=?0.31 SD/5?µmol/L (0.10-0.51)] and higher triceps [??=?0.38?mm/5?µmol/L (95% CI 0.11-0.65)] and subscapular skinfold thicknesses [??=?0.26?mm/5?µmol/L (95% CI 0.01-0.50)] at birth. No consistent trends were observed between maternal choline and offspring gain in body mass index skinfold thicknesses abdominal circumference weight length/height and adiposity measures in later infancy and early childhood. Conclusion: Our study provides evidence that maternal circulating choline concentrations during pregnancy are positively associated with offspring BMI, skinfold thicknesses and adiposity at birth but not with growth and adiposity through infancy and early childhood to the age of 5?years. |
Source Title: | International Journal of Epidemiology | URI: | https://scholarbank.nus.edu.sg/handle/10635/155529 | ISSN: | 1464-3685 | DOI: | 10.1093/ije/dyy291 |
Appears in Collections: | Staff Publications Elements |
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