Please use this identifier to cite or link to this item: https://doi.org/10.1093/ije/dyy291
Title: Prospective associations of maternal choline status with offspring body composition in the first 5 years of life in two large mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort
Authors: van Lee L
Crozier SR
Aris IM 
Tint MT 
Sadananthan SA 
Michael N
Quah PL 
Robinson SM
Inskip HM
Harvey NC
Barker M
Cooper C
Velan SS 
Lee YS 
Fortier MV 
Yap F 
Gluckman PD 
Tan KH 
Shek LP 
Chong YS 
Godfrey KM
Chong MFF 
Keywords: choline
pregnancy
offspring
body composition
birth size
Issue Date:  11
Citation: van Lee L, Crozier SR, Aris IM, Tint MT, Sadananthan SA, Michael N, Quah PL, Robinson SM, Inskip HM, Harvey NC, Barker M, Cooper C, Velan SS, Lee YS, Fortier MV, Yap F, Gluckman PD, Tan KH, Shek LP, Chong YS, Godfrey KM, Chong MFF (11/1/2019). Prospective associations of maternal choline status with offspring body composition in the first 5 years of life in two large mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort. International Journal of Epidemiology 48 (2) : 433-444. ScholarBank@NUS Repository. https://doi.org/10.1093/ije/dyy291
Abstract: Background: Choline status has been positively associated with weight and fat mass in animal and human studies. As evidence examining maternal circulating choline concentrations and offspring body composition in human infants/children is lacking
we investigated this in two cohorts. Methods: Maternal choline concentrations were measured in the UK Southampton Women's Survey (SWS; serum
n?=?985
11?weeks' gestation) and Singapore Growing Up Towards healthy Outcomes (GUSTO); n?=?955
26-28?weeks' gestation) mother-offspring cohorts. Offspring anthropometry was measured at birth and up to age 5?years. Body fat mass was determined using dual-energy x-ray absorptiometry at birth and age 4?years for SWS; and using air-displacement plethysmography at birth and age 5?years for GUSTO. Linear-regression analyses were performed, adjusting for confounders. Results: In SWS
higher maternal choline concentrations were associated with higher neonatal total body fat mass {??=?0.60 standard deviation [SD]/5?µmol/L maternal choline [95% confidence interval (CI) 0.04-1.16]} and higher subscapular skinfold thickness [??=?0.55?mm/5?µmol/L (95% CI
0.12-1.00)] at birth. In GUSTO, higher maternal choline concentrations were associated with higher neonatal body mass index-for-age z-score [??=?0.31 SD/5?µmol/L (0.10-0.51)] and higher triceps [??=?0.38?mm/5?µmol/L (95% CI
0.11-0.65)] and subscapular skinfold thicknesses [??=?0.26?mm/5?µmol/L (95% CI
0.01-0.50)] at birth. No consistent trends were observed between maternal choline and offspring gain in body mass index
skinfold thicknesses
abdominal circumference
weight
length/height and adiposity measures in later infancy and early childhood. Conclusion: Our study provides evidence that maternal circulating choline concentrations during pregnancy are positively associated with offspring BMI, skinfold thicknesses and adiposity at birth
but not with growth and adiposity through infancy and early childhood to the age of 5?years.
Source Title: International Journal of Epidemiology
URI: https://scholarbank.nus.edu.sg/handle/10635/155529
ISSN: 1464-3685
DOI: 10.1093/ije/dyy291
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