Please use this identifier to cite or link to this item: https://doi.org/10.1002/ijc.31857
Title: A NOVEL SOCS5/MIR-18/MIR-25 AXIS PROMOTES TUMORIGENESIS IN LIVER CANCER
Authors: Sanchez-Mejias, A 
Kwon, J
Chew, XH 
Siemens, A
Sohn, HS
Jing, G 
Zhang, B 
Yang, H 
Tay, Y 
Keywords: SOCS5
hepatocellular carcinoma
miR-18a
miR-25
suppressor of cytokines
Carcinogenesis
Carcinoma, Hepatocellular
Gene Expression Regulation, Neoplastic
Humans
Liver Neoplasms
MicroRNAs
Suppressor of Cytokine Signaling Proteins
Issue Date: 15-Jan-2019
Publisher: Wiley
Citation: Sanchez-Mejias, A, Kwon, J, Chew, XH, Siemens, A, Sohn, HS, Jing, G, Zhang, B, Yang, H, Tay, Y (2019-01-15). A NOVEL SOCS5/MIR-18/MIR-25 AXIS PROMOTES TUMORIGENESIS IN LIVER CANCER 144 (2) : 311-321. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.31857
Abstract: © 2018 UICC The role of miRNAs with tumor suppressive activity in liver cancer has been well studied. However, little is known about potential oncomiRs in HCC. In our study, we conducted a systematic evaluation of candidate oncomiRs and found that upregulation of miR-18a and miR-25 in HCC was associated with poor patient survival and promoted proliferation in HCC cell lines. These two miRNAs belong to the polycistronic paralogous miR-17-92 and miR-25-106b clusters respectively. Although the members of both clusters are often upregulated in HCC, the contribution of individual miRNAs in these clusters to HCC tumorigenesis is not fully understood. We validated SOCS5 as a bona fide target of both miRNAs, and established, for the first time, the tumor suppressive role of SOCS5 in liver cancer. We further investigated the mechanism by which SOCS5 contributes to tumorigenesis, demonstrated that this SOCS5/miR-18a/miR-25 axis regulates the tumor suppressor TSC1 and downstream mTOR signaling, and highlighted the potential therapeutic use of miR-18a and miR-25 inhibition in restoring SOCS5 levels in HCC.
URI: https://scholarbank.nus.edu.sg/handle/10635/155415
ISSN: 0020-7136
1097-0215
DOI: 10.1002/ijc.31857
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