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https://doi.org/10.1002/ijc.31857
Title: | A NOVEL SOCS5/MIR-18/MIR-25 AXIS PROMOTES TUMORIGENESIS IN LIVER CANCER | Authors: | Sanchez-Mejias, A Kwon, J Chew, XH Siemens, A Sohn, HS Jing, G Zhang, B Yang, H Tay, Y |
Keywords: | SOCS5 hepatocellular carcinoma miR-18a miR-25 suppressor of cytokines Carcinogenesis Carcinoma, Hepatocellular Gene Expression Regulation, Neoplastic Humans Liver Neoplasms MicroRNAs Suppressor of Cytokine Signaling Proteins |
Issue Date: | 15-Jan-2019 | Publisher: | Wiley | Citation: | Sanchez-Mejias, A, Kwon, J, Chew, XH, Siemens, A, Sohn, HS, Jing, G, Zhang, B, Yang, H, Tay, Y (2019-01-15). A NOVEL SOCS5/MIR-18/MIR-25 AXIS PROMOTES TUMORIGENESIS IN LIVER CANCER 144 (2) : 311-321. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.31857 | Abstract: | © 2018 UICC The role of miRNAs with tumor suppressive activity in liver cancer has been well studied. However, little is known about potential oncomiRs in HCC. In our study, we conducted a systematic evaluation of candidate oncomiRs and found that upregulation of miR-18a and miR-25 in HCC was associated with poor patient survival and promoted proliferation in HCC cell lines. These two miRNAs belong to the polycistronic paralogous miR-17-92 and miR-25-106b clusters respectively. Although the members of both clusters are often upregulated in HCC, the contribution of individual miRNAs in these clusters to HCC tumorigenesis is not fully understood. We validated SOCS5 as a bona fide target of both miRNAs, and established, for the first time, the tumor suppressive role of SOCS5 in liver cancer. We further investigated the mechanism by which SOCS5 contributes to tumorigenesis, demonstrated that this SOCS5/miR-18a/miR-25 axis regulates the tumor suppressor TSC1 and downstream mTOR signaling, and highlighted the potential therapeutic use of miR-18a and miR-25 inhibition in restoring SOCS5 levels in HCC. | URI: | https://scholarbank.nus.edu.sg/handle/10635/155415 | ISSN: | 0020-7136 1097-0215 |
DOI: | 10.1002/ijc.31857 |
Appears in Collections: | Staff Publications Elements |
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A novel SOCS5:miR-18:miR-25 axis promotes tumorigenesis in liver cancer.pdf | Published version | 1 MB | Adobe PDF | OPEN | None | View/Download |
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