Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsnano.7b04685
Title: Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics
Authors: GUO, BING 
SHENG, ZONGHAI
HU, DEHONG
LI, ANRAN
XU, SHIDANG 
MANGHNANI, PURNIMA NARESH
LIU, CHENGBO
GUO, LIN 
ZHENG, HAIRONG
LIU, BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
conjugated polymer nanoparticles
molecular engineering
theranostic platform
tumor
photoacoustic imaging
photothermal therapy
LIVING MICE
CONTRAST AGENTS
GRAPHENE OXIDE
THERAPY
NANOMATERIALS
ABSORPTION
NANOMEDICINES
NANOSHEETS
DOTS
TIME
Issue Date: 1-Oct-2017
Publisher: AMER CHEMICAL SOC
Citation: GUO, BING, SHENG, ZONGHAI, HU, DEHONG, LI, ANRAN, XU, SHIDANG, MANGHNANI, PURNIMA NARESH, LIU, CHENGBO, GUO, LIN, ZHENG, HAIRONG, LIU, BIN (2017-10-01). Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics. ACS NANO 11 (10) : 10124-10134. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.7b04685
Abstract: © 2017 American Chemical Society. Conjugated polymer nanoparticles (CP NPs) are emerging candidates of "all-in-one" theranostic nanoplatforms with dual photoacoustic imaging (PA) and photothermal therapy (PTT) functions. So far, very limited molecular design guidelines have been developed for achieving CPs with highly efficient PA and PTT performance. Herein, by designing CP1, CP2, and CP3 using different electron acceptors (A) and a planar electron donor (D), we demonstrate how the D-A strength affects their absorption, emission, extinction coefficient, and ultimately PA and PTT performance. The resultant CP NPs have strong PA signals with high photothermal conversion efficiencies and excellent biocompatibility in vitro and in vivo. The CP3 NPs show a high PA signal to background ratio of 47 in U87 tumor-bearing mice, which is superior to other reported PA/PTT theranostic agents. A very small IC 50 value of 0.88 μg/mL (CP3 NPs) was obtained for U87 glioma cell ablation under laser irradiation (808 nm, 0.8 W/cm 2 , 5 min). This study shows that CP NP based theranostic platforms are promising for future personalized nanomedicine.
Source Title: ACS NANO
URI: https://scholarbank.nus.edu.sg/handle/10635/155308
ISSN: 19360851
1936086X
DOI: 10.1021/acsnano.7b04685
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