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https://doi.org/10.1021/acsnano.7b04685
Title: | Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics | Authors: | GUO, BING SHENG, ZONGHAI HU, DEHONG LI, ANRAN XU, SHIDANG MANGHNANI, PURNIMA NARESH LIU, CHENGBO GUO, LIN ZHENG, HAIRONG LIU, BIN |
Keywords: | Science & Technology Physical Sciences Technology Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science conjugated polymer nanoparticles molecular engineering theranostic platform tumor photoacoustic imaging photothermal therapy LIVING MICE CONTRAST AGENTS GRAPHENE OXIDE THERAPY NANOMATERIALS ABSORPTION NANOMEDICINES NANOSHEETS DOTS TIME |
Issue Date: | 1-Oct-2017 | Publisher: | AMER CHEMICAL SOC | Citation: | GUO, BING, SHENG, ZONGHAI, HU, DEHONG, LI, ANRAN, XU, SHIDANG, MANGHNANI, PURNIMA NARESH, LIU, CHENGBO, GUO, LIN, ZHENG, HAIRONG, LIU, BIN (2017-10-01). Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics. ACS NANO 11 (10) : 10124-10134. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.7b04685 | Abstract: | © 2017 American Chemical Society. Conjugated polymer nanoparticles (CP NPs) are emerging candidates of "all-in-one" theranostic nanoplatforms with dual photoacoustic imaging (PA) and photothermal therapy (PTT) functions. So far, very limited molecular design guidelines have been developed for achieving CPs with highly efficient PA and PTT performance. Herein, by designing CP1, CP2, and CP3 using different electron acceptors (A) and a planar electron donor (D), we demonstrate how the D-A strength affects their absorption, emission, extinction coefficient, and ultimately PA and PTT performance. The resultant CP NPs have strong PA signals with high photothermal conversion efficiencies and excellent biocompatibility in vitro and in vivo. The CP3 NPs show a high PA signal to background ratio of 47 in U87 tumor-bearing mice, which is superior to other reported PA/PTT theranostic agents. A very small IC 50 value of 0.88 μg/mL (CP3 NPs) was obtained for U87 glioma cell ablation under laser irradiation (808 nm, 0.8 W/cm 2 , 5 min). This study shows that CP NP based theranostic platforms are promising for future personalized nanomedicine. | Source Title: | ACS NANO | URI: | https://scholarbank.nus.edu.sg/handle/10635/155308 | ISSN: | 19360851 1936086X |
DOI: | 10.1021/acsnano.7b04685 |
Appears in Collections: | Staff Publications Elements |
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