Please use this identifier to cite or link to this item: https://doi.org/10.1002/adma.201802591
Title: Through Scalp and Skull NIR-II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance
Authors: GUO, BING 
SHENG, ZONGHAI
HU, DEHONG
LIU, CHENGBO
ZHENG, HAIRONG
LIU, BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
brain tumor
NIR-II
photoacoustic imaging
photothermal therapy
precision theranostics
PHOTODYNAMIC THERAPY
IN-VIVO
CONJUGATED POLYMER
DRUG-RESISTANCE
STEM-CELLS
NANOPARTICLES
GLIOBLASTOMA
DELIVERY
GLIOMA
WINDOW
Issue Date: 29-Aug-2018
Publisher: WILEY-V C H VERLAG GMBH
Citation: GUO, BING, SHENG, ZONGHAI, HU, DEHONG, LIU, CHENGBO, ZHENG, HAIRONG, LIU, BIN (2018-08-29). Through Scalp and Skull NIR-II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance. ADVANCED MATERIALS 30 (35). ScholarBank@NUS Repository. https://doi.org/10.1002/adma.201802591
Abstract: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Brain tumor is one of the most lethal cancers owing to the existence of blood–brain barrier and blood–brain tumor barrier as well as the lack of highly effective brain tumor treatment paradigms. Herein, cyclo(Arg-Gly-Asp-D-Phe-Lys(mpa)) decorated biocompatible and photostable conjugated polymer nanoparticles with strong absorption in the second near-infrared (NIR-II) window are developed for precise photoacoustic imaging and spatiotemporal photothermal therapy of brain tumor through scalp and skull. Evidenced by the higher efficiency to penetrate scalp and skull for 1064 nm laser as compared to common 808 nm laser, NIR-II brain-tumor photothermal therapy is highly effective. In addition, via a real-time photoacoustic imaging system, the nanoparticles assist clear pinpointing of glioma at a depth of almost 3 mm through scalp and skull with an ultrahigh signal-to-background ratio of 90. After spatiotemporal photothermal treatment, the tumor progression is effectively inhibited and the survival spans of mice are significantly extended. This study demonstrates that NIR-II conjugated polymer nanoparticles are promising for precise imaging and treatment of brain tumors.
Source Title: ADVANCED MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/155305
ISSN: 09359648
15214095
DOI: 10.1002/adma.201802591
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