Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsami.8b22579
Title: Microfluidics-Prepared Uniform Conjugated Polymer Nanoparticles for Photo-Triggered Immune Microenvironment Modulation and Cancer Therapy
Authors: WANG, ZHE
GUO, BING 
MIDDHA, ESHU
HUANG, ZEMIN
HU, QINGLIAN 
FU, ZHENGWEI
LIU, BIN 
Keywords: Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
immune tumor microenvironment
conjugated polymer nanoparticles
photothermal therapy
cancer
microfluidics
TUMOR-ASSOCIATED MACROPHAGES
ORGANIC NANOPARTICLES
IN-VITRO
IMMUNOTHERAPY
NANOMATERIALS
METASTASIS
BRIGHT
AGENTS
OXIDE
VIVO
Issue Date: 27-Mar-2019
Publisher: AMER CHEMICAL SOC
Citation: WANG, ZHE, GUO, BING, MIDDHA, ESHU, HUANG, ZEMIN, HU, QINGLIAN, FU, ZHENGWEI, LIU, BIN (2019-03-27). Microfluidics-Prepared Uniform Conjugated Polymer Nanoparticles for Photo-Triggered Immune Microenvironment Modulation and Cancer Therapy. ACS APPLIED MATERIALS & INTERFACES 11 (12) : 11167-11176. ScholarBank@NUS Repository. https://doi.org/10.1021/acsami.8b22579
Abstract: © 2019 American Chemical Society. Photothermal therapy (PTT) has shown great promise to spatiotemporally ablate cancer cells, and further understanding of the immune system response to PTT treatment would contribute to improvement in therapeutic outcomes. Herein, we utilize microfluidic technology to prepare biocompatible conjugated polymer nanoparticles (CP NPs) as PTT agents and assess the immune response triggered by CP-based PTT treatment in vitro and in vivo. Through careful control of the antisolvent, CP NPs with a uniform diameter of 52 nm were obtained. The c-RGD-functionalized CP NPs exhibit high photothermal conversion efficiency, inducing effective cancer cell death under an 808 nm laser illumination. Using macrophage cells as the model, CP NPs demonstrate effective activation of proinflammatory immune response. Furthermore, in tumor-bearing mice model, a single round of CP NP-assisted PTT could efficiently induce antitumor immunity activation and ultimately inhibit tumor growth. The study provides detailed understanding of both microfluidic technology for CP NP fabrication and photothermal-triggered antitumor immune responses.
Source Title: ACS APPLIED MATERIALS & INTERFACES
URI: https://scholarbank.nus.edu.sg/handle/10635/155302
ISSN: 19448244
19448252
DOI: 10.1021/acsami.8b22579
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2019-ACS AMI-February 27, 2019.pdfPublished version4.55 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

30
checked on Nov 27, 2021

Page view(s)

226
checked on Nov 18, 2021

Download(s)

3
checked on Nov 18, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.