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Title: Improvement in the design and operation of Bio-reactors and Bio-separators based on SMB Technology
Authors: ZHANG YAN
Keywords: Simulated Moving Bed, Varicol, Optimization, Genetic Algorithm, High Fructose Syrup, Racemic Pindolol
Issue Date: 17-Nov-2006
Citation: ZHANG YAN (2006-11-17). Improvement in the design and operation of Bio-reactors and Bio-separators based on SMB Technology. ScholarBank@NUS Repository.
Abstract: This dissertation presents comprehensive study on the optimal design and operation of simulated moving bed (SMB) reactors and separators for two systems, i.e., (a) production of high fructose syrup (HFS) by isomerization of glucose and (b) enantio-separation of racemic pindolol. Multi-objective optimization of both the famous Hashimotoa??s SMBR system and a modified system with fewer reactors were conducted for isomerization of glucose using the elitist non-dominated sorting genetic algorithm with jumping genes (NSGA-II-JG). Both productivity and purity of fructose have been increased significantly by applying multi-objective optimization. And the 4-section modified SMBR with one or two reactors could achieve the same or even better performance obtained by Hashimotoa??s system with 7 reactors due to the sufficient separation of glucose and fructose at the inlet of each reactor. Results from the theoretical and experimental investigations of SMB and Varicol process for enantioseparation of racemic pindolol on Chiral-AGP stationary phase indicated that the short-cut design strategy based on Triangle Theory could give a rather accurate prediction of the separation performance. In addition, higher feed concentration and higher recycling flow rate were desirable in improving both recovery and purity of the two enantiomers.
Appears in Collections:Ph.D Theses (Open)

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