Please use this identifier to cite or link to this item: https://doi.org/10.1038/ni.3694
DC FieldValue
dc.titleEssential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells
dc.contributor.authorKreslavsky, Taras
dc.contributor.authorVilagos, Bojan
dc.contributor.authorTagoh, Hiromi
dc.contributor.authorPoliakova, Daniela Kostanova
dc.contributor.authorSchwickert, Tanja A
dc.contributor.authorWoehner, Miriam
dc.contributor.authorJaritz, Markus
dc.contributor.authorWeiss, Siegfried
dc.contributor.authorTaneja, Reshma
dc.contributor.authorRossner, Moritz J
dc.contributor.authorBusslinger, Meinrad
dc.date.accessioned2019-06-06T06:13:16Z
dc.date.available2019-06-06T06:13:16Z
dc.date.issued2017-04-01
dc.identifier.citationKreslavsky, Taras, Vilagos, Bojan, Tagoh, Hiromi, Poliakova, Daniela Kostanova, Schwickert, Tanja A, Woehner, Miriam, Jaritz, Markus, Weiss, Siegfried, Taneja, Reshma, Rossner, Moritz J, Busslinger, Meinrad (2017-04-01). Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. NATURE IMMUNOLOGY 18 (4) : 442-+. ScholarBank@NUS Repository. https://doi.org/10.1038/ni.3694
dc.identifier.issn15292908
dc.identifier.issn15292916
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/155225
dc.description.abstract© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. Innate-like B-1a cells provide a first line of defense against pathogens, yet little is known about their transcriptional control. Here we identified an essential role for the transcription factor Bhlhe41, with a lesser contribution by Bhlhe40, in controlling B-1a cell differentiation. Bhlhe41-/- Bhlhe40-/- B-1a cells were present at much lower abundance than were their wild-type counterparts. Mutant B-1a cells exhibited an abnormal cell-surface phenotype and altered B cell receptor (BCR) repertoire exemplified by loss of the phosphatidylcholine-specific VH 12V κ4 BCR. Expression of a pre-rearranged VH 12V κ4 BCR failed to 'rescue' the mutant phenotype and revealed enhanced proliferation accompanied by increased cell death. Bhlhe41 directly repressed the expression of cell-cycle regulators and inhibitors of BCR signaling while enabling pro-survival cytokine signaling. Thus, Bhlhe41 controls the development, BCR repertoire and self-renewal of B-1a cells.
dc.language.isoen
dc.publisherNATURE PUBLISHING GROUP
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectImmunology
dc.subjectCENTER B-CELL
dc.subjectPOSITIVE SELECTION
dc.subjectFETAL
dc.subjectEXPRESSION
dc.subjectDISTINCT
dc.subjectSINGLE
dc.subjectMICE
dc.subjectIDENTIFICATION
dc.subjectPROLIFERATION
dc.subjectLYMPHOPOIESIS
dc.typeArticle
dc.date.updated2019-06-03T08:57:48Z
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.1038/ni.3694
dc.description.sourcetitleNATURE IMMUNOLOGY
dc.description.volume18
dc.description.issue4
dc.description.page442-+
dc.description.placeUnited States
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Essential role of the transcription factor-preprint.pdf4.66 MBAdobe PDF

OPEN

Pre-printView/Download

SCOPUSTM   
Citations

20
checked on Oct 20, 2019

WEB OF SCIENCETM
Citations

16
checked on Jul 17, 2019

Page view(s)

51
checked on Oct 17, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.