Please use this identifier to cite or link to this item:
https://doi.org/10.1038/ni.3694
DC Field | Value | |
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dc.title | Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells | |
dc.contributor.author | Kreslavsky, Taras | |
dc.contributor.author | Vilagos, Bojan | |
dc.contributor.author | Tagoh, Hiromi | |
dc.contributor.author | Poliakova, Daniela Kostanova | |
dc.contributor.author | Schwickert, Tanja A | |
dc.contributor.author | Woehner, Miriam | |
dc.contributor.author | Jaritz, Markus | |
dc.contributor.author | Weiss, Siegfried | |
dc.contributor.author | Taneja, Reshma | |
dc.contributor.author | Rossner, Moritz J | |
dc.contributor.author | Busslinger, Meinrad | |
dc.date.accessioned | 2019-06-06T06:13:16Z | |
dc.date.available | 2019-06-06T06:13:16Z | |
dc.date.issued | 2017-04-01 | |
dc.identifier.citation | Kreslavsky, Taras, Vilagos, Bojan, Tagoh, Hiromi, Poliakova, Daniela Kostanova, Schwickert, Tanja A, Woehner, Miriam, Jaritz, Markus, Weiss, Siegfried, Taneja, Reshma, Rossner, Moritz J, Busslinger, Meinrad (2017-04-01). Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. NATURE IMMUNOLOGY 18 (4) : 442-+. ScholarBank@NUS Repository. https://doi.org/10.1038/ni.3694 | |
dc.identifier.issn | 15292908 | |
dc.identifier.issn | 15292916 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/155225 | |
dc.description.abstract | © 2017 Nature America, Inc., part of Springer Nature. All rights reserved. Innate-like B-1a cells provide a first line of defense against pathogens, yet little is known about their transcriptional control. Here we identified an essential role for the transcription factor Bhlhe41, with a lesser contribution by Bhlhe40, in controlling B-1a cell differentiation. Bhlhe41-/- Bhlhe40-/- B-1a cells were present at much lower abundance than were their wild-type counterparts. Mutant B-1a cells exhibited an abnormal cell-surface phenotype and altered B cell receptor (BCR) repertoire exemplified by loss of the phosphatidylcholine-specific VH 12V κ4 BCR. Expression of a pre-rearranged VH 12V κ4 BCR failed to 'rescue' the mutant phenotype and revealed enhanced proliferation accompanied by increased cell death. Bhlhe41 directly repressed the expression of cell-cycle regulators and inhibitors of BCR signaling while enabling pro-survival cytokine signaling. Thus, Bhlhe41 controls the development, BCR repertoire and self-renewal of B-1a cells. | |
dc.language.iso | en | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Immunology | |
dc.subject | CENTER B-CELL | |
dc.subject | POSITIVE SELECTION | |
dc.subject | FETAL | |
dc.subject | EXPRESSION | |
dc.subject | DISTINCT | |
dc.subject | SINGLE | |
dc.subject | MICE | |
dc.subject | IDENTIFICATION | |
dc.subject | PROLIFERATION | |
dc.subject | LYMPHOPOIESIS | |
dc.type | Article | |
dc.date.updated | 2019-06-03T08:57:48Z | |
dc.contributor.department | DEPT OF PHYSIOLOGY | |
dc.description.doi | 10.1038/ni.3694 | |
dc.description.sourcetitle | NATURE IMMUNOLOGY | |
dc.description.volume | 18 | |
dc.description.issue | 4 | |
dc.description.page | 442-+ | |
dc.description.place | United States | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Essential role of the transcription factor-preprint.pdf | 4.66 MB | Adobe PDF | OPEN | Pre-print | View/Download |
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