Please use this identifier to cite or link to this item: https://doi.org/10.1089/ars.2017.7158
Title: Stressing the (Epi)Genome: Dealing with Reactive Oxygen Species in Cancer
Authors: Bhat, Akshay V 
Hora, Shainan
Pal, Ananya
Jha, Sudhakar 
Taneja, Reshma 
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Endocrinology & Metabolism
ROS
epigenetics
cancer
therapeutics
HISTONE DEACETYLASE INHIBITOR
NF-KAPPA-B
FOLATE SUPPLEMENTATION LIMITS
NADPH OXIDASE NOX5-S
RENAL-CELL CARCINOMA
HUMAN COLON CANCERS
OXIDATIVE STRESS
DNA METHYLATION
PROSTATE-CANCER
BREAST-CANCER
Issue Date: 1-Nov-2018
Publisher: MARY ANN LIEBERT, INC
Citation: Bhat, Akshay V, Hora, Shainan, Pal, Ananya, Jha, Sudhakar, Taneja, Reshma (2018-11-01). Stressing the (Epi)Genome: Dealing with Reactive Oxygen Species in Cancer. ANTIOXIDANTS & REDOX SIGNALING 29 (13) : 1273-1292. ScholarBank@NUS Repository. https://doi.org/10.1089/ars.2017.7158
Abstract: © 2018, Mary Ann Liebert, Inc., publishers. Significance: Growing evidence indicates cross-talk between reactive oxygen species (ROS) and several key epigenetic processes such as DNA methylation, histone modifications, and miRNAs in normal physiology and human pathologies including cancer. This review focuses on how ROS-induced oxidative stress, metabolic intermediates, and epigenetic processes influence each other in various cancers. Recent Advances: ROS alter chromatin structure and metabolism that impact the epigenetic landscape in cancer cells. Several site-specific DNA methylation changes have been identified in different cancers and are discussed in the review. We also discuss the interplay of epigenetic enzymes and miRNAs in influencing malignant transformation in an ROS-dependent manner. Critical Issues: Loss of ROS-mediated signaling mostly by epigenetic regulation may promote tumorigenesis. In contrast, augmented oxidative stress because of high ROS levels may precipitate epigenetic alterations to effect various phases of carcinogenesis. We address both aspects in the review. Future Directions: Several drugs targeting ROS are under various stages of clinical development. Recent analysis of human cancers has revealed pervasive deregulation of the epigenetic machinery. Thus, a better understanding of the cross-talk between ROS and epigenetic alterations in cancer could lead to the identification of new drug targets and more effective treatment modalities.
Source Title: ANTIOXIDANTS & REDOX SIGNALING
URI: https://scholarbank.nus.edu.sg/handle/10635/155220
ISSN: 1523-0864
1557-7716
DOI: 10.1089/ars.2017.7158
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