Please use this identifier to cite or link to this item:
https://doi.org/10.3324/haematol.2018.202911
DC Field | Value | |
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dc.title | Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias | |
dc.contributor.author | Lao, ZT | |
dc.contributor.author | Ding, LW | |
dc.contributor.author | An, O | |
dc.contributor.author | Hattori, N | |
dc.contributor.author | Sun, QY | |
dc.contributor.author | Tan, KT | |
dc.contributor.author | Mayakonda, A | |
dc.contributor.author | Chuan, WG | |
dc.contributor.author | Madan, V | |
dc.contributor.author | Lin, DC | |
dc.contributor.author | Yang, H | |
dc.contributor.author | Koeffler, HP | |
dc.date.accessioned | 2019-06-06T01:22:41Z | |
dc.date.available | 2019-06-06T01:22:41Z | |
dc.date.issued | 2019-05-01 | |
dc.identifier.citation | Lao, ZT, Ding, LW, An, O, Hattori, N, Sun, QY, Tan, KT, Mayakonda, A, Chuan, WG, Madan, V, Lin, DC, Yang, H, Koeffler, HP (2019-05-01). Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias. Haematologica 104 (5) : e200-e203. ScholarBank@NUS Repository. https://doi.org/10.3324/haematol.2018.202911 | |
dc.identifier.issn | 0390-6078 | |
dc.identifier.issn | 1592-8721 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/155184 | |
dc.description.abstract | Acute leukemia of ambiguous lineage (ALAL) is a rare group of blood cancers that cannot be clearly classified into either myeloid or lymphoid lineage through traditional immunophenotyping (2016 World Health Organization classification). In this study, we performed exome and transcriptome sequencing of 15 diagnosis/relapse samples to identify mutations of this disease. Remarkably, genes involved in DNA repair pathway were frequently mutated and occurred in 80% of the samples. In addition, well known mutations of hematopoietic neoplasms were found in these samples, such as DNMT3A, RUNX1, NOTCH1 and NRAS. A number of ALAL samples simultaneously harboured mutations of both myeloid and lymphoid neoplasm associated genes, which may explain (at least partially) the mixed lineage phenotype of this abnormality. Our study provides novel insights into this rare leukemic entity which may help to develop a better therapeutic strategy. Copyright © 2018, Ferrata Storti Foundation. | |
dc.publisher | Ferrata Storti Foundation (Haematologica) | |
dc.source | Elements | |
dc.subject | 0604 Genetics | |
dc.subject | 1112 Oncology and Carcinogenesis | |
dc.subject | Biomedical | |
dc.subject | Basic Science | |
dc.subject | Pediatric Cancer | |
dc.subject | Childhood Leukemia | |
dc.subject | Cancer | |
dc.subject | Human Genome | |
dc.subject | Pediatric Research Initiative | |
dc.subject | Hematology | |
dc.subject | Genetics | |
dc.subject | Pediatric | |
dc.subject | Clinical Research | |
dc.subject | Rare Diseases | |
dc.subject | Cancer | |
dc.subject | 2.1 Biological and endogenous factors | |
dc.type | Letter | |
dc.date.updated | 2019-06-03T08:00:24Z | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.contributor.department | DEPT OF MEDICINE | |
dc.description.doi | 10.3324/haematol.2018.202911 | |
dc.description.sourcetitle | Haematologica | |
dc.description.volume | 104 | |
dc.description.issue | 5 | |
dc.description.page | e200-e203 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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2018-mutational_transcriptomic_profiling_acute_leukemia-published.pdf | 1.19 MB | Adobe PDF | OPEN | Published | View/Download |
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