Please use this identifier to cite or link to this item:
Title: Studies of the anti-metastatic potential of emodin on human tumor cells
Keywords: emodin; cancer; metastasis; invasion; migration; adhesion
Issue Date: 28-Aug-2006
Citation: HUANG QING (2006-08-28). Studies of the anti-metastatic potential of emodin on human tumor cells. ScholarBank@NUS Repository.
Abstract: Tumor metastasis is a complex process that involves several interdependent events: angiogenesis, adhesion, migration and invasion. Identification of potential agents that effectively act to interrupt various steps of metastatic cascade could be of great clinical significance. In this study, the anti-metastatic property of emodin, an active component from the rhizome of Rheum palmatum, has been systematically clarified: first, emodin inhibits the invasiveness of human cancer cells by suppressing matrix metalloproteinase-9 expression through inhibition of activator protein-1 and nuclear factor kappaB signaling; Second, emodin suppresses tumor cell migration through phosphatidylinositol 3-kinase-Cdc42/Rac1 signaling pathway; Third, emodin inhibits cancer cell adhesion through cholesterol reduction in the membrane lipid rafts and subsequent disruption of the lipid rafts-associated integrin signaling. These findings suggest that emodin interferes with tumor metastasis at several pivotal points and it could be of therapeutic value in preventing metastasis of human cancers.
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Ph D thesis by Huang Qing.pdf4.32 MBAdobe PDF



Page view(s)

checked on Apr 20, 2019


checked on Apr 20, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.