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Title: Isolation, characterisation and/or evaluation of plant extracts for anticancer potential
Keywords: triterpenoids, anticancer, cytotoxicity, MTT assay, lethal dosages, in vitro
Issue Date: 25-Aug-2006
Citation: KARUPPIAH PILLAI MANOHARAN (2006-08-25). Isolation, characterisation and/or evaluation of plant extracts for anticancer potential. ScholarBank@NUS Repository.
Abstract: Chloroform and hexane fractions of Polygonum bistorta (Polygonaceae) and their sub-fractions were screened for their anticancer potential against selected cancer cell lines. Some showed very good activity against P388, HL60 and LL2 cancer cell lines. Both active and non-active fractions were investigated for their phytochemical constituents. Ten compounds were isolated including three new and one rarely encountered compounds. The crude extract, chloroform and hexane fractions were evaluated for their toxicity in Swiss albino mice. Similarly fractions and sub-fractions of the mushroom, Lasiosphaera nipponica were investigated both phytochemically and pharmacologically; one known compound was isolated and a few fractions showed anticancer activity in vitro. A total of nine compounds were isolated from Eugenia grandis, including one new and one rarely encountered compounds. One known compound was isolated from Juglans regia; several known compounds were identified from an oily liquid by GC-MS analysis. Two known compounds were isolated from Fagrae fragrans. Extracts of Houttuynia cordata and a mixture of six herbs were evaluated for their cytotoxicity.
Appears in Collections:Ph.D Theses (Open)

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