Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/154109
Title: PREVALENCE, PREDICTORS AND OUTCOMES OF CENTRAL LINE-ASSOCIATED BLOODSTREAM INFECTIONS AMONG PATIENTS RECEIVING HAEMATOPOIETIC STEM CELL TRANSPLANT
Authors: TAN PIN YAN @TAN LI LING
Keywords: Predictors
Risk factors
Central line-associated bloodstream infections
Catheter-related bloodstream infections
Haemopoietic stem cell transplant
Issue Date: 25-May-2019
Citation: TAN PIN YAN @TAN LI LING (2019-05-25). PREVALENCE, PREDICTORS AND OUTCOMES OF CENTRAL LINE-ASSOCIATED BLOODSTREAM INFECTIONS AMONG PATIENTS RECEIVING HAEMATOPOIETIC STEM CELL TRANSPLANT. ScholarBank@NUS Repository.
Abstract: Aims: To determine the prevalence, predictors and outcomes of haemopoietic stem cell transplant (HSCT) patients in Singapore Background: Central line-associated bloodstream infection (CLABSI) was concluded as a significant risk factor of mortality after HSCT, even though it is preventable. There is a scarcity of research on adults HSCT patients in Singapore’s context. The findings will provide baseline data to evaluate CLABSI and used to generate useful CLABSI prevention initiatives, ultimately improving patient care. Methods: An observational retrospective chart review study was conducted on HSCT patients from 1st July 2016 to 31st October 2017 using total population sampling. The patients’ medical records were retrieved from the hospital’s electronic database. Data analysis was performed using univariate analysis and logistic regression on Statistical Package for Social Sciences Version 25. Results: CLABSI rate was 5.62 episodes. Univariate analyses indicated statistical significance in cancer diagnosis (p < .001), conditioning regime (p = .002), graft type (p = 0.043), donor type (p = .004), central venous catheter (CVC) type (p = .002), CVC site (p = 0.042), history of CLABSI (p < .001), presence of line occlusions (p < .001), neutropenia during CLABSI (p < .001), blood products transfusion within 7 days before onset of CLABSI (p < .001) and duration of CVC (p = 0.03). However, logistic regression only concluded CVC type, history of CLABSI, presence of line occlusions and cancer diagnosis as predictors of CLABSI. The aetiology of CLABSI was revealed to be mainly gram-negative bacteria and multidrug resistant bacteria. Conclusion and Implications: Interesting findings of line occlusions and history of CLABSI, as a predictors of CLABSI, illuminated areas for further studies to validate these uncommon findings. The CLABSI pathogens identified have also highlighted clinical practices that can be improved. Overall, this study provides a baseline of data on CLABSI in Singapore and identifies areas for further research.
URI: https://scholarbank.nus.edu.sg/handle/10635/154109
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