Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/154105
Title: EFFECTIVENESS OF EARLY ADMINISTRATION OF STANDARD ENTERAL FEEDING POST-PANCREATICODUODENECTOMY SURGERY IN REDUCING LENGTH OF HOSPITAL STAY: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: SUM HSIN YIN CLAIRE
Keywords: Pancreaticoduodenectomy
Enteral nutrition
Parenteral nutrition
Length of stay
Solid diet
Systematic review
Issue Date: 25-May-2019
Citation: SUM HSIN YIN CLAIRE (2019-05-25). EFFECTIVENESS OF EARLY ADMINISTRATION OF STANDARD ENTERAL FEEDING POST-PANCREATICODUODENECTOMY SURGERY IN REDUCING LENGTH OF HOSPITAL STAY: A SYSTEMATIC REVIEW AND META-ANALYSIS. ScholarBank@NUS Repository.
Abstract: Background: Pancreaticoduodenectomy (PD) is the main treatment option for patients with cancer of the head of pancreas, a malignancy with increasing global prevalence. It is important that patients receive proper nutrition post-PD to prevent malnutrition. However, it is poorly understood if enteral nutrition (EN) or parenteral nutrition (PN) is more effective for recovery. Objectives: To review current available evidence to determine the effectiveness of EN as compared to PN in lowering the hospital length of stay (HLOS), and on reducing the time to initiate solid diet. Methods: A systematic search of six databases (CINAHL, Embase, ProQuest Dissertations and Theses, PubMed, Scopus and The Cochrane Library) was conducted. Published primary research studies, including randomised controlled trials and retrospective studies, reporting the effectiveness of EN compared to PN in patients post-PD were deemed eligible for inclusion. Two independent reviewers extracted data and assessed the quality of the studies. Meta-analyses were conducted for the primary and secondary outcomes, followed by sensitivity testing and subgroup analyses where appropriate. Results: Eight studies (nine arms) were included in this review. Meta-analysis on the primary outcome revealed that EN significantly lowers the HLOS of post-PD patients, as opposed to PN (MD=1.74, 95% CI [0.46 to 3.01], p=0.008). The secondary outcome of initiation of solid diet showed no significant difference whether EN or PN was used (MD=0.84, 95% CI [-1.02 to 2.70], p=0.37). Conclusions and Implications: EN is more beneficial than PN in reducing the HLOS, but the time to initiate solid diet was not influenced by the route of adminstration. More high quality RCTs can be conducted in future, for a wider number to allow physicians to make more informed decisions on the route of artificial nutrition administration best suited for their patients.
URI: https://scholarbank.nus.edu.sg/handle/10635/154105
Appears in Collections:Bachelor's Theses

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
SUM HSIN YIN CLAIRE_A0142342U.pdf1.13 MBAdobe PDF

RESTRICTED

NoneLog In

Page view(s)

29
checked on Jul 10, 2020

Download(s)

25
checked on Jul 10, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.