Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/154096
Title: EFFECTIVENESS OF LUNG CANCER SCREENING USING LOW-DOSE COMPUTED TOMOGRAPHY AMONG MALE CHRONIC SMOKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: SARAH FOO XIAO HAN
Keywords: Smokers
Low-dose Computed Tomography
LDCT
Lung Cancer Screening
Lung Cancer
Issue Date: 25-May-2019
Citation: SARAH FOO XIAO HAN (2019-05-25). EFFECTIVENESS OF LUNG CANCER SCREENING USING LOW-DOSE COMPUTED TOMOGRAPHY AMONG MALE CHRONIC SMOKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS. ScholarBank@NUS Repository.
Abstract: Background: Lung cancer poses a major health problem globally, especially among male chronic smokers. It has been established that early-stage lung cancer has much better prognosis, therefore, early detection through cancer screening would be beneficial. The use of Low-Dose Computed Tomography (LDCT) as a lung cancer screening modality appears to be promising. However, no existing reviews has assessed the effectiveness of lung cancer screening using LDCT among male chronic smokers. Aims: This systematic review aims to evaluate the effectiveness of lung cancer screening using LDCT among male chronic smokers, with regards to lung cancer detection and lung cancer mortality reduction. Methods: Eight electronic databases and reference lists of relevant articles were searched to identify eligible randomised controlled trials (RCTs). Two reviewers independently screened the potential studies for eligibility. One reviewer extracted the study data and a second reviewer checked through. All included studies were assessed for their risk of bias and the outcomes were appraised for their overall quality of evidence. Results: A total of 2,656 articles were screened. Three RCTs with a total of 36,247 participants were included in this review. The pooled analysis showed no statistically significant difference in lung cancer detection and lung cancer mortality reduction between participants in the screening and control group. The subgroup analysis did, however, identify significant difference in lung cancer detection between the screening and control group. Implications for practice and future research: Longer-duration trials are recommended so as to better assess for mortality reduction. Public awareness should be raised with regards to the use of LDCT as a lung cancer screening instrument. Conclusion: LDCT provided optimistic results with regards to lung cancer detection but more studies are required to evaluate the effects on mortality reduction.
URI: https://scholarbank.nus.edu.sg/handle/10635/154096
Appears in Collections:Bachelor's Theses

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