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Title: Surface modification of the electroactive polymer, polypyrrole, and its applications as a biomaterial
Authors: LI YALI
Keywords: surface modification; polypyrrole; heparin; hydrogel; controlled release; electrical stimulation
Issue Date: 23-Jun-2006
Citation: LI YALI (2006-06-23). Surface modification of the electroactive polymer, polypyrrole, and its applications as a biomaterial. ScholarBank@NUS Repository.
Abstract: The surface functionalization of the electroactive polymer, polypyrrole (PPY), for biological applications with and without electrical stimulation was investigated. In the first part of the project, PPY with covalently immobilized heparin on its surface was shown to possess good bioactivity. Electrical stimulation also plays a positive role in enhancing the bioactivity of the PPY films. The surface modification technique was further extended to covalently immobilize a layer of poly(vinyl alcohol) (PVA)-heparin hydrogel on the PPY film. The release behavior of heparin from the PPY-PVA substrate depended on the swellability of the substrate as well as the degree of electrical stimulation. The experimental results showed that the heparin release rate can be controlled in a pulsatile fashion using electrical stimulation. The release rate obtained when a current of 3.5 mA is passed through the PPY is two-fold higher than that without electrical stimulation. Lastly, an electrically conductive, hydrophilic and microporous PPY-PVA composite was prepared electrochemically and its potential as a biomaterial was investigated with respect to its blood compatibility and function as a substrate for biosensor fabrication and cell culture.
Appears in Collections:Ph.D Theses (Open)

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