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Title: Mechanisms of hypochlorous acid-mediated neuronal cell death
Keywords: hypochlorous acid, calpain, caspase, cathepsin, apoptosis, oxidative stress
Issue Date: 25-May-2006
Citation: YAP YANN WAN (2006-05-25). Mechanisms of hypochlorous acid-mediated neuronal cell death. ScholarBank@NUS Repository.
Abstract: The current study reports for the first time that HOCl mediates concentration-dependent apoptosis-necrotic continuum neuronal cell death. Neurotoxicity caused by 250 I?M HOCl exhibited several biochemical markers of apoptosis in the absence of caspase activation. Yet, caspase-independent pathways such as calpain activation and lysosomal pathway are involved. Furthermore, microarray analysis reveals the upregulation of orphan nuclear receptor Nr4a1 that engaged in caspase-independent cell death. In addition, three survival mechanisms such as suppression of cell cycle genes, induction of programmed cell life pathway and salvage of cellular energy were also identified at gene expression level. In conclusion, the participation of calpain, cathepsins, Nr4a1 and defense mechanisms in the neurotoxicity of HOCl enables them to be targeted for multiple disorders which HOCl is found associated. As a result, this study offers a novel potential therapeutic area for the disease and probably allow clinical research to mature from a??a??promisea??a?? to a??a??practicea??a??.
Appears in Collections:Master's Theses (Open)

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