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Title: Studies on spheronization processes by rotary and extrusion
Authors: GU LI
Keywords: Pellets; Rotary processing; Extrusion spheronization; Crospovidone; Lactose.
Issue Date: 20-Jun-2006
Citation: GU LI (2006-06-20). Studies on spheronization processes by rotary and extrusion. ScholarBank@NUS Repository.
Abstract: Pellets were prepared using two pelletization methods of rotary processing and extrusion spheronization. The effects of various equipment design, formulation and process variables on the quality of final products were investigated. Two variables were identified as important in affecting quality of the pellets prepared by rotary processing. In rotary processing, a new frictional plate design with teardrop shaped studs was tested to achieve good process reproducibility, desirable pellet characteristics and minimal material adhesion. In rotary processing, pre-mixing step could be eliminated to make the rotary processing a truly one-pot process. Effect of lactose particle size was investigated in two spheronization processes for assisting the choice of most favorable lactose grade. Crospovidone was evaluated for its ability to function as spheronization aid in extrusion spheronization. Crospovidone pellets were of equivalent quality to those prepared with MCC showing the potential of crospovidone as a competent alternative to MCC in pelletization.
Appears in Collections:Ph.D Theses (Open)

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