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Title: Positional clustering and co-expression analysis of neighboring genes in the zebrafish genome
Authors: WU WEI
Keywords: Positional Clustering, Co-expression, Zebrafish, Microarray, Neighboring Gene
Issue Date: 14-Aug-2006
Citation: WU WEI (2006-08-14). Positional clustering and co-expression analysis of neighboring genes in the zebrafish genome. ScholarBank@NUS Repository.
Abstract: Microarray experiments provide deep insight into molecular evolution and how structure and function interrelate in a genome.Our study investigates whether neighboring and clustering genes in the zebrafish genome are co-expressed using the Affymetrix microarray data. Tandem duplicated genes are found to have a higher degree of co-expression than other neighboring genes in the analysis.A further analysis of the data set relates to the effect of intergenic distance. A significant correlation between distance and co-expression is found.We also study the positional clustering of genes in the zebrafish genome. A significant trend for large clusters is recognized. A positive correlation between the significance of positional clustering and the degree of neighboring gene co-expression is also found in the genome.Finally, we study the co-expression of genes with their gene ontology information, and find that the molecular function plays an important role in the gene co-expression.
Appears in Collections:Master's Theses (Open)

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