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Title: Hepatitis B virus gene mutations associated with HBeAg seroconversion
Authors: CHENG YAN
Keywords: HBV, chronic hepaitis B, HBeAg, seroconversion, mutations
Issue Date: 17-Apr-2006
Citation: CHENG YAN (2006-04-17). Hepatitis B virus gene mutations associated with HBeAg seroconversion. ScholarBank@NUS Repository.
Abstract: HBeAg seroconversion is an important clinicopathological event in the natural history of chronic hepatitis B. The relation between viral mutations and this event were explored. Genotype B was associated with higher prevalence rates of seroconversion. Sequencing of the core promoter showed that seroconverters had universally mutations that affected at least one transcription factor binding site. The possibility of mixed HBV viral species was tested for 4-5 time point samples of different groups of patients. Denaturing gradient gels demonstrated that only seroconverters had a high proportion of quasispecies. Analysis of precore/core sequences showed that there was considerably viral divergence and heterogeneity, most marked in spontaneous seroconverters, and somewhat less so for interferon induced seroconverters but a considerably lower rate of mutations in non-seroconverters. Separately, study of selected mutations that affected HBeAg secretion was demonstrated. In summary, HBV mutations have a significant impact on viral behavior and natural history of the disease.
Appears in Collections:Ph.D Theses (Open)

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