Please use this identifier to cite or link to this item:
Title: Anti-myeloma effects of icariin are mediated through the attenuation of JAK/STAT3-dependent signaling cascade
Authors: Jung Y.Y.
Lee J.H.
Nam D.
Narula A.S.
Namjoshi O.A.
Blough B.E.
Um J.-Y.
Sethi G. 
Ahn K.S.
Keywords: Apoptosis; Icariin; JAKs; Multiple myeloma; STAT3
Issue Date: 2018
Publisher: Frontiers Media S.A.
Citation: Jung Y.Y., Lee J.H., Nam D., Narula A.S., Namjoshi O.A., Blough B.E., Um J.-Y., Sethi G., Ahn K.S. (2018). Anti-myeloma effects of icariin are mediated through the attenuation of JAK/STAT3-dependent signaling cascade. Frontiers in Pharmacology 9 (MAY) : 531. ScholarBank@NUS Repository.
Abstract: Because of the essential role of signal transducer and activator of transcription 3 (STAT3) in proliferation, anti-apoptosis, and chemoresistance of multiple myeloma (MM), we investigated whether icariin, a prenylated flavonol glycoside, inhibits both constitutive and inducible STAT3 activation in human myeloma cell lines. We noted that icariin could block constitutive STAT3 phosphorylation as well as its nuclear translocation and DNA binding ability in U266 cells. Icariin also suppressed IL-6-induced STAT3 activation through the inhibition of upstream kinases (Janus activated kinase-1 and -2, and c-Src). We found that icariin downregulated the protein expression of STAT3 downstream target gene products such as Bcl-2, Bcl-xl, survivin, IAP-1/2, COX-2, VEGF, and matrix metallopeptidase 9 (MMP-9) in a concentration-dependent manner. Moreover, this flavonoid also exhibited the capacity to significantly induce apoptosis and suppress proliferation of MM cells. Interestingly, this agent also significantly potentiated the apoptotic effects of bortezomib through the suppression of STAT3 activation in MM cells. Altogether, our data indicates that the potential application of icariin as a STAT3 blocker in myeloma therapy. © 2018 Jung, Lee, Nam, Narula, Namjoshi, Blough, Um, Sethi and Ahn.
Source Title: Frontiers in Pharmacology
ISSN: 16639812
DOI: 10.3389/fphar.2018.00531
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
fphar.2018.00531.pdf3.38 MBAdobe PDF




checked on Jul 21, 2021


checked on Jul 16, 2019

Page view(s)

checked on Jul 23, 2021


checked on Jul 23, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.