Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-28106-5
Title: Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation
Authors: Chen E.W.
Brzostek J. 
Gascoigne N.R.J. 
Rybakin V. 
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Chen E.W., Brzostek J., Gascoigne N.R.J., Rybakin V. (2018). Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation. Scientific Reports 8 (1) : 10046. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-28106-5
Abstract: Activation of the T cell receptor (TCR) leads to the generation of a network of signaling events critical to the developmental decision making and activation of T cells. Various experimental approaches continue to identify new signaling molecules, adaptor proteins, and other regulators of TCR signaling. We propose a screening strategy for the identification of small molecules affecting TCR signaling based on the uncoupling of TCR stimulation from cellular responses in developing thymocytes. We demonstrate that this strategy successfully identifies inhibitors of kinases already shown to act downstream of TCR engagement, as well as new inhibitors. The proposed strategy is easily scalable for high throughput screening and will contribute to the identification of new druggable targets in T cell activation. © 2018 The Author(s).
Source Title: Scientific Reports
URI: http://scholarbank.nus.edu.sg/handle/10635/152524
ISSN: 20452322
DOI: 10.1038/s41598-018-28106-5
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