Please use this identifier to cite or link to this item:
Title: Epigenomic control of thermogenic adipocyte differentiation and function
Authors: Peng X.
Zhang Q.
Liao C.
Han W.
Xu F. 
Keywords: Adipocyte; DNA methylation; Epigenome; Histone modification; Thermogenesis
Issue Date: 2018
Publisher: MDPI AG
Citation: Peng X., Zhang Q., Liao C., Han W., Xu F. (2018). Epigenomic control of thermogenic adipocyte differentiation and function. International Journal of Molecular Sciences 19 (6) : 1-14. ScholarBank@NUS Repository.
Abstract: Obesity and its associated metabolic disorders are spreading at a fast pace throughout the world; thus, effective therapeutic approaches are necessary to combat this epidemic. Obesity develops when there is a greater caloric intake than energy expenditure. Promoting energy expenditure has recently attracted much attention as a promising approach for the management of body weight. Thermogenic adipocytes are capable of burning fat to dissipate chemical energy into heat, thereby enhancing energy expenditure. After the recent re-discovery of thermogenic adipocytes in adult humans, much effort has focused on understanding the molecular mechanisms, especially the epigenetic mechanisms, which regulate thermogenic adipocyte development and function. A number of chromatin signatures, such as histone modifications, DNA methylation, chromatin accessibilities, and interactions, have been profiled at the genome level and analyzed in various murine and human thermogenic fat cell systems. Moreover, writers and erasers, as well as readers of the epigenome are also investigated using genomic tools in thermogenic adipocytes. In this review, we summarize and discuss the recent advance in these studies and highlight the insights gained into the epigenomic regulation of thermogenic program as well as the pathogenesis of human metabolic diseases. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
ISSN: 16616596
DOI: 10.3390/ijms19061793
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ijms19061793.pdf1.02 MBAdobe PDF




checked on Jul 16, 2019

Page view(s)

checked on Jul 18, 2019


checked on Jul 18, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.