Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tranon.2018.08.015
Title: Sorcin a Potential Molecular Target for Cancer Therapy
Authors: Shabnam B.
Padmavathi G.
Banik K.
Girisa S.
Monisha J.
Sethi G. 
Fan L.
Wang L. 
Mao X.
Kunnumakkara A.B.
Issue Date: 2018
Publisher: Neoplasia Press, Inc.
Citation: Shabnam B., Padmavathi G., Banik K., Girisa S., Monisha J., Sethi G., Fan L., Wang L., Mao X., Kunnumakkara A.B. (2018). Sorcin a Potential Molecular Target for Cancer Therapy. Translational Oncology 11 (6) : 1379-1389. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tranon.2018.08.015
Abstract: Sorcin (Soluble resistance related calcium binding protein) is a small soluble penta EF family (PEF) of calcium (Ca2+) binding protein (22,000 Da). It has been reported to play crucial roles in the regulation of calcium homeostasis, apoptosis, vesicle trafficking, cancer development, and multidrug resistance (MDR). Overexpression of sorcin has been reported to be associated with different cancers such as breast cancer, colorectal cancer, gastric cancer, leukemia, lung cancer, nasopharyngeal cancer, ovarian cancer, etc. Essentially, expression of sorcin has been found to be elevated in cancer cells as compared to normal cells, indicating that it has prominent role in cancer. Moreover, sorcin was found to be the regulator of various proteins that has an association with carcinogenesis including NF-?B, STAT3, Akt, ERK1/2, VEGF, MMPs, caspases, etc. Sorcin was also found to regulate apoptosis, as silencing of the same resulted in increased levels of proapoptotic genes and induced mitochondrial apoptotic pathway in cancer. Interestingly, mutations in the sorcin gene have been closely linked with poor overall survival in bladder cancer, brain lower-grade glioma, glioblastoma, glioblastoma multiforme, kidney renal clear cell carcinoma, and stomach adenocarcinoma. Additionally, overexpression of sorcin was also found to induce MDR against different chemotherapeutic drugs. All these findings mark the importance of sorcin in cancer development and MDR. Therefore, there is urgent need to explore the functional mechanism of sorcin and to analyze whether silencing of sorcin would able to chemosensitize MDR cells. The current review summarizes the structure, expression, and functions of sorcin and its importance in the regulation of various malignancies and MDR. © 2018 The Authors
Source Title: Translational Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/152125
ISSN: 19365233
DOI: 10.1016/j.tranon.2018.08.015
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
j.tranon.2018.08.015.pdf639.76 kBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

3
checked on Oct 15, 2019

WEB OF SCIENCETM
Citations

1
checked on Jul 16, 2019

Page view(s)

41
checked on Oct 17, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.