Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ebiom.2018.08.047
DC FieldValue
dc.titleMetformin from mother to unborn child - Are there unwarranted effects?
dc.contributor.authorNguyen L.
dc.contributor.authorChan S.-Y.
dc.contributor.authorTeo A.K.K.
dc.date.accessioned2019-03-06T05:06:19Z
dc.date.available2019-03-06T05:06:19Z
dc.date.issued2018
dc.identifier.citationNguyen L., Chan S.-Y., Teo A.K.K. (2018). Metformin from mother to unborn child - Are there unwarranted effects?. EBioMedicine 35 : e0202554. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ebiom.2018.08.047
dc.identifier.issn23523964
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/152028
dc.description.abstractFor more than 40 years, metformin has been used before and during pregnancy. However, it is important to note that metformin can cross the placenta and circulate in the developing foetus. Recent studies reported that the concentration of metformin in foetal cord blood ranges from half to nearly the same concentration as in the maternal plasma. Since metformin has anti-cell growth and pro-apoptotic effects, there are persistent concerns over the use of metformin in early pregnancy. Current human studies are limited by sample size, lack of controls or, short follow-up durations. In this review, we examine the settings in which metformin can be passed on from mother to child during pregnancy and address the current controversies relating to the cellular and molecular mechanisms of metformin. Our efforts highlight the need for more data on the effects of metformin on general offspring health as well as further scrutiny into foetal development upon exposure to metformin. � 2018 The Authors
dc.publisherElsevier B.V.
dc.sourceScopus
dc.subjectDevelopment
dc.subjectGDM
dc.subjectGestational diabetes
dc.subjectMetformin
dc.subjectPCOS
dc.subjectPolycystic ovary syndrome
dc.subjectPregnancy
dc.typeReview
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/j.ebiom.2018.08.047
dc.description.sourcetitleEBioMedicine
dc.description.volume35
dc.description.pagee0202554
dc.grant.idSIF
dc.grant.idNRF
dc.grant.idA*STAR
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idNMRC/CSA-INV/0010/2016
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.idIMCB
dc.grant.fundingagencySingapore International Foundation
dc.grant.fundingagencyNational Research Foundation Singapore
dc.grant.fundingagencyAgency for Science, Technology and Research
dc.grant.fundingagencyNMRC, National Medical Research Council
dc.grant.fundingagencyNMRC, National Medical Research Council
dc.grant.fundingagencyNMRC, National Medical Research Council
dc.grant.fundingagencyInstitute of Molecular and Cell Biology
Appears in Collections:Elements
Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
j.ebiom.2018.08.047.pdf1.26 MBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

6
checked on Aug 4, 2020

WEB OF SCIENCETM
Citations

2
checked on Jul 17, 2019

Page view(s)

214
checked on Jul 31, 2020

Download(s)

1
checked on Jul 31, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.