Please use this identifier to cite or link to this item:
Title: Investigations on the antiplasmodial activity of ferrocenyl chalcones
Authors: WU XIANG
Keywords: ferrocenyl chalcone, antiplasmodial activity, QSAR analysis, oxidant property, heme binding, parasite-induced permeation pathways
Issue Date: 22-May-2006
Citation: WU XIANG (2006-05-22). Investigations on the antiplasmodial activity of ferrocenyl chalcones. ScholarBank@NUS Repository.
Abstract: A series of ferrocenyl chalcones were synthesized and their antiplasmodial activities were evaluated. A structure-activity relationship study was carried out with multivariate tools and the mode of antiplasmodial action was also investigated.About 1/3rd of the ferrocenyl chalcones showed antiplasmodial activity with IC50 values less than 20 i?-M. The most active compounds were 1-(3a??-pyridinyl)-3-ferrocenyl-2-propen-1-one (6) (IC50 4.6 i?-M) and 1-ferrocenyl-3-(4a??-nitrophenyl)-2-propen-1-one (28) (IC50 5.1 i?-M).In the QSAR study, oxidizability of ferrocene and the polarity of carbonyl linkage were identified as important parameters for antiplasmodial activity.The investigations on the scavenging of ABTS radical cation and free radical generation showed that ferrocenyl chalcones could generate free radicals rapidly but without a robust correlation with their antiplasmodial activity.In conclusion, the study has shown that ferrocenyl chalcones demonstrated antiplasmodial activity in vitro. Ferrocene was found to markedly affect the physicochemical properties of ferrocenyl chalcones and to influence antiplasmodial activity of these compounds.
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Thesis of Wu Xiang.pdf1.76 MBAdobe PDF



Page view(s)

checked on Apr 19, 2019


checked on Apr 19, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.