Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/151867
Title: INVESTIGATING THE CLINICAL AND MOLECULAR ASPECTS OF THE DIAGNOSIS OF BARRETT?s ESOPHAGUS ? AN ASIAN PERSPECTIVE
Authors: NEEL SHARMA
Keywords: Barrett's Esophagus, Symptoms, Risk Stratification, Real Time Diagnosis, FABP, CEACAM 6
Issue Date: 26-Jan-2018
Citation: NEEL SHARMA (2018-01-26). INVESTIGATING THE CLINICAL AND MOLECULAR ASPECTS OF THE DIAGNOSIS OF BARRETT?s ESOPHAGUS ? AN ASIAN PERSPECTIVE. ScholarBank@NUS Repository.
Abstract: Barrett’s esophagus (BE) is a premalignant condition associated with the development of esophageal adenocarcinoma. We noted that in Asia, reflux symptoms are non-diagnostic of BE. Endoscopically we performed a real time diagnosis study of Barrett’s esophagus. We noted that neither white light endoscopy or probe based confocal laser endomicroscopy as modalities were sufficiently strong to confirm a diagnosis of BE. From a molecular marker perspective, we noted for the first time that FABP was most accurate for the diagnosis of BE. We also proved for the first time that HEPAR was diagnostic of Barrett’s associated dysplasia. We localised for the first time CEACAM6 as a novel marker for BE. We also demonstrated its potential as a fluorescently tagged marker for enhanced endoscopic detection.
URI: http://scholarbank.nus.edu.sg/handle/10635/151867
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