Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/151848
Title: VOLATILE ORGANIC COMPOUNDS ANALYSIS AND METABOLOMICS FOR EARLY DETECTION OF LUNG CANCER
Authors: JIA ZHUNAN
Keywords: Volatile organic compounds, breath analysis, metabolomics, lung cancer, GC-MS, SIFT-MS
Issue Date: 31-Jul-2018
Citation: JIA ZHUNAN (2018-07-31). VOLATILE ORGANIC COMPOUNDS ANALYSIS AND METABOLOMICS FOR EARLY DETECTION OF LUNG CANCER. ScholarBank@NUS Repository.
Abstract: Breath volatile organic compounds analysis is an emerging field that holds potential to become a low cost and non-invasive disease detection tool. So far volatile biomarkers for most diseases are unknown. In this thesis we focus on identifying VOCs associated with lung cancer using a combination of clinical and in-vitro approaches. Two clinical studies using SIFT-MS and GC/MS were conducted. Several key confounders to breath analysis were identified. A combination of 8 VOCs achieved diagnostic sensitivity and specificity of 85% and 76% respectively, they could be used as potential biomarkers for lung cancer detection. Study of VOCs emitted by seven different lung cell lines in culture showed significant discrimination between lung cancer and normal cells. Different histological types of lung cancer cell lines also showed unique VOC profiles. Possible biochemical pathways for these VOCs were revealed by a correlation test of metabolites and VOCs from these cell lines.
URI: http://scholarbank.nus.edu.sg/handle/10635/151848
Appears in Collections:Ph.D Theses (Open)

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