Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/151842
Title: REVEALING THE PHYSICAL BASIS OF VINCULIN DEPENDENT MECHANOSENSING OF CELLS
Authors: WANG YINAN
Keywords: Mechanobiology, Vinculin, Talin, Single-molecule manipulation
Issue Date: 23-Aug-2018
Citation: WANG YINAN (2018-08-23). REVEALING THE PHYSICAL BASIS OF VINCULIN DEPENDENT MECHANOSENSING OF CELLS. ScholarBank@NUS Repository.
Abstract: Force sensing is crucial for cells to regulate their adhesions to extracellular matrix (ECM) through integrin-based focal adhesions (FAs) or to neighboring cells through cadherin based cell-cell adherence junctions (AJs) in tissues. Vinculin is a crucial protein mediating mechanosensing at FA and AJ through binding to talin and alpha-catenin, two force-bearing cytoplasmic adapters that link FA and AJ to actin network, respectively. In my Ph.D studies, I apply magnetic tweezers based mechanical manipulation of single molecules to investigate the molecular mechanisms of the vinculin dependent mechanosensing from three aspects. 1) Force-dependent vinculin binding to talin. 2) The mechanical response of full-length vinculin. 3) Developing technology to enable control vinculin mediated mechanosensing in cells.
URI: http://scholarbank.nus.edu.sg/handle/10635/151842
Appears in Collections:Ph.D Theses (Restricted)

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