Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2018.06.021
Title: Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines
Authors: Ferraiuolo M.
Pulito C.
Finch-Edmondson M. 
Korita E.
Maidecchi A.
Donzelli S.
Muti P.
Serra M.
Sudol M. 
Strano S.
Blandino G.
Keywords: Agave
Osteosarcoma
Proliferation
Saponins
YAP/TAZ
Issue Date: 2018
Publisher: Elsevier Ireland Ltd
Citation: Ferraiuolo M., Pulito C., Finch-Edmondson M., Korita E., Maidecchi A., Donzelli S., Muti P., Serra M., Sudol M., Strano S., Blandino G. (2018). Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines. Cancer Letters 433 : 18-32. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2018.06.021
Abstract: Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are required. Research into new anticancer therapies has paved the way for the utilisation of natural compounds as they are typically less expensive and less toxic compared to conventional chemotherapeutics. Previously published works indicate that Agave exhibits anticancer properties, however potential molecular mechanisms remain poorly understood. In the present study, we investigate the anticancer effects of Agave leaf extract in OS cells suggesting that Agave inhibits cell viability, colony formation, and cell migration, and can induce apoptosis in OS cell lines. Moreover, Agave sensitizes OS cells to cisplatin (CDDP) and radiation, to overcome chemo- and radio-resistance. We demonstrate that Agave extract induces a marked decrease of Yes Associated Protein (YAP) and Tafazzin (TAZ) mRNA and protein expression upon treatment. We propose an initial mechanism of action in which Agave induces YAP/TAZ protein degradation, followed by a secondary event whereby Agave inhibits YAP/TAZ transcription, effectively deregulating the Nuclear Factor kappa B (NF-?B) p65:p50 heterodimers responsible for transcriptional induction of YAP and TAZ. © 2018 The Authors
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/151650
ISSN: 03043835
DOI: 10.1016/j.canlet.2018.06.021
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
j.canlet.2018.06.021.pdf3.59 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

11
checked on Sep 21, 2020

WEB OF SCIENCETM
Citations

2
checked on Jul 17, 2019

Page view(s)

115
checked on Sep 18, 2020

Download(s)

1
checked on Sep 18, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.