Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/151572
Title: ACTIVITY OF NEURONS IN PRIMATE HIPPOCAMPUS DURING SPATIAL NAVIGATION
Authors: BELLE LIM WAN LING
Keywords: single-cell recording, spatial navigation, hippocampus, path cells, primate
Issue Date: 9-Nov-2018
Citation: BELLE LIM WAN LING (2018-11-09). ACTIVITY OF NEURONS IN PRIMATE HIPPOCAMPUS DURING SPATIAL NAVIGATION. ScholarBank@NUS Repository.
Abstract: Spatial navigation is an essential part of our daily lives. Extensive research highlights the hippocampus as a key neural structure of spatial navigation. While place cells within the hippocampus are integral in encoding spatial information across an environment, recent studies identified the presence of a cell type unique to the entorhinal cortex (i.e., EC path cells). This study extends the findings of EC path cells, to investigate their presence in the hippocampus and parahippocampal brain regions. This study hypothesizes that path cells will be present in the targeted regions and exemplify spatial selectivity within the environment. An in vivo single-cell recording method was used to analyse patterns of neuronal activity of one male long-tailed macaque during clockwise and counterclockwise route traversal in a virtual reality navigation task. We were able to confirm the existence of path cells and further showed that this selectivity is not spatially localized, but rather a general property across locations. In a broader context, these findings extend the hippocampal cognitive map theory as a centre characterized by both spatial and non-spatial memory systems, in integrating information about the environment and creating internal representations to aid navigation in the real world.
URI: http://scholarbank.nus.edu.sg/handle/10635/151572
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